- Approval Id
- c7514821ca978dac
- Drug Name
- PRENOLOL 50 TABLET 50 mg
- Product Name
- PRENOLOL 50 TABLET 50 mg
- Approval Number
- SIN10277P
- Approval Date
- 1998-10-14
- Registrant
- POLYMEDIC TRADING ENTERPRISE PTE LTD
- Licence Holder
- POLYMEDIC TRADING ENTERPRISE PTE LTD
- Drug Type
- Therapeutic
- Forensic Classification
- Prescription Only
- Dosage Form
- TABLET, FILM COATED
- Dosage
- <p><strong>DOSAGE AND ADMINISTRATION</strong></p>
<p><strong>Adults</strong></p>
<p><strong>Hypertension</strong></p>
<p>Most patients respond to 50–100 mg daily given orally as a single daily dose. The effect will be fully established after one to two weeks. A further reduction in blood pressure may be achieved by combining “Prenolol” with other antihypertensive agents.</p>
<p><strong>Angina</strong></p>
<p>Most patients with angina pectoris will respond to 100 mg daily given orally as a single dose or as 50 mg given twice a day. It is unlikely that additional benefit will be gained by increasing the dose.</p>
<p><strong>Elderly</strong></p>
<p>Dosage requirement may be reduced, especially in patients with impaired renal function.</p>
<p><strong>Children</strong></p>
<p>There is no paediatric experience with “Prenolol” and for this reason it is not recommended for use in children.</p>
<p><strong>Renal Failure</strong></p>
<p>Since “Prenolol” is excreted via the kidneys dosage should be reduced in cases of severe impairment of renal function. No significant accumulation of “Prenolol” occurs in patients who have a creatinine clearance greater than 35 ml/min/1.73 m<sup>2</sup> (normal range is 100–150 ml/min/1.73 m<sup>2</sup>). For patients with a creatinine clearange of 15–35 ml/min/1.73 m<sup>2</sup> (equivalent to serum creatinine of 300–600 micromole/litre) the oral dose should be 50 mg daily. For patients with a creatinine clearance of <15 ml/min/1.73 m<sup>2</sup> (equivalent to serum creatinine of >600 micromole/litre) the oral dose should be 25 mg daily or 50 mg on alternate days.</p>
<p>Patients on haemodialysis should be given 50 mg orally after each dialysis : this should be done under hospital supervision as marked falls in blood pressure can occur.</p>
- Route Of Administration
- ORAL
- Indication Info
- <p><strong>INDICATIONS</strong></p>
<ol class="romanparen">
<li>Hypertension</li>
<li>Angina pectoris</li>
<li>Cardiac arrhythmias</li>
<li>Myocardial infarction. Early and late intervention.</li>
</ol>
- Contraindications
- <p><strong>CONTRA-INDICATIONS</strong></p>
<p>“Prenolol” as with other beta-blockers, should not be used in patients with any of the following : known hypersensitivity to the substance ; bradycardia ; cardiogenic shock ; hypotension ; metabolic acidosis ; severe peripheral arterial circulatory disturbances ; second or third degree heart block ; sick sinus syndrome ; untreated phaeochromocytoma ; uncontrolled heart failure.</p>
- Atc Code
- C07AB03
- Atc Item Name
- atenolol
- Pharma Manufacturer Name
- POLYMEDIC TRADING ENTERPRISE PTE LTD
