DEXMEDETOMIDINE KALCEKS CONCENTRATE FOR SOLUTION FOR INFUSION 100MCG/ML

INFUSION, SOLUTION CONCENTRATE

**4.2 Posology and method of administration** Dosing guidelines - Dosing should be individualized and titrated to desired clinical response. - This medicinal product is not indicated for infusions lasting longer than 24 hours. - This medicinal product should be administered using a controlled infusion device. Posology  Dosage adjustment Due to possible pharmacodynamic interactions, a reduction in dosage of dexmedetomidine or other concomitant anaesthetics, sedatives, hypnotics or opioids may be required when co-administered (see section 4.5 – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_). Dosage reductions may need to be considered for adult patients with hepatic impairment, and geriatric patients (see sections 4.4 and 5.2 – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_). Method of administration This medicine must be administered only as a diluted intravenous infusion using a controlled infusion device. For instructions on dilution of the medicinal product before administration, see section 6.7 – _please refer to the Product Insert/Patient Information Leaflet published on HSA for the full drug information_.