VYTAN FILM-COATED TABLET 80 MG

TABLET, FILM COATED

**X. DOSAGE AND ADMINISTRATION** **Hypertension** The recommended dose of valsartan is 80 mg once daily, irrespective of race, age, or gender. The maximum antihypertensive effect is seen after 4 weeks. In patients whose blood pressure is not adequately controlled, the daily dose may be increased to 160mg. If additional blood pressure reduction is required, a diuretic may be added or the dose can be increased further to a maximum of 320 mg. Valsartan may also be administered with other antihypertensive agents. **Heart failure** The recommended starting dose of Valsartan is 40 mg film-coated tablet twice daily. Up-titration to 80mg and 160 mg twice daily should be done to the highest dose tolerated by the patient. Consideration should be given to reducing the dose of concomitant diuretics. The maximum daily dose administered is 320 mg in divided doses. Evaluation of patients with heart failure should always include assessment of renal function. **Post-myocardial infarction** Therapy may be initiated as early as 12 hours after a myocardial infarction. After an initial dose of 20mg twice daily, valsartan therapy should be titrated to 40 mg, 80 mg, and 160 mg film-coated tablet twice daily over the next few weeks. The starting dose is provided by the 40 mg divisible tablet. Achievement of the target dose of 160mg twice daily should be based on the patient’s tolerability to valsartan during titration. If symptomatic hypotension or renal dysfunction occurs, consideration should be given to a dosage reduction. Valsartan may be used in patients treated with other post-myocardial infarction therapies, e.g. thrombolytics, acetylsalicylic acid, beta blockers or statins. Evaluation of post-myocardial infarction patients should always include assessment of renal function. NOTE for all indications: No dosage adjustment is required for patients with renal impairment or for patients with hepatic insufficiency of non-biliary origin and without cholestasis. **Use in children and adolescents** The safety and efficacy of Valsartan have not been established in children and adolescents (below the age of 18 years). **Method of administration** Film-coated tablets: Valsartan may be taken independently of a meal and should be administered with water. Route of Administration: Oral Tablet can be divided into equal halves.