VIRLESS TABLET 800 mg

YUNG SHIN PHARMACEUTICAL (SINGAPORE) PTE LTD

YUNG SHIN PHARMACEUTICAL (SINGAPORE) PTE LTD

Therapeutic

Prescription Only

TABLET

**Dosage and Administration:** **I. Adult dose:** _Treatment of Herpes Simplex Infection:_ 200mg (400mg in the immunocompromised patient) 5 times daily, usually for 5 days. _Prevention of recurrent Herpes Simplex Infection:_ 200mg to be taken 4 times daily, or 400mg twice daily, possibly reduced to 200mg 2 or 3 times daily. Therapy should be interrupted periodically at interval 6 – 12 months in order to observe possible changes in the nature history of the disease. _Prophylaxis of Herpes Simplex Infection in immunocompromised patients:_ 200mg to be taken 4 times daily at approximately 6 hours interval. In situation of severe immunocompromised, eg., after bone marrow transplantation, or in patients with impaired gastrointestinal absorption, the dose may be doubled to 400mg. _Treatment of Varicella and Herpes Zoster infection:_ 800mg, 5 times daily for 7 days. **II. Pediatric Dose:** For treatment of Herpes Simplex Infection and for _Prophylaxis of Herpes Simplex Infection_ in immunocompromised, children 2 years and over should be given adult dosage, and children < 2 years should be given half the adult dose. For treatment of Varicella Infection, children > 6 years: 800mg 4 times a day.2 – 6 years: 400mg 4 times a day.below 2 years: 200mg 4 times a day. Dosing may be calculated as 20mg/kg body weight (not to exceed 800mg), 4 times daily. Treatment should be continued for 5 days. No specific data are available on the treatment of Herpes Simplex Infection in immune-competent children. **III. Dosage in Elderly** Elderly patients are more likely to have an age-related decrease in renal function, which may required an adjustment of dosage or dosing interval. **IV. Dosage in Renal Impairment** For patient with renal impairment (creatinine clearance < 10ml/min), the dosage should be decreased to 200mg every 12 hours for treatment of _Herpes Simplex Infection_, and 800mg twice daily for treatment of _Varicella and Zoster Infection_.