KETAMINE HYDROCHLORIDE INJECTION USP

DUOPHARMA (SINGAPORE) PTE LTD

DUOPHARMA (SINGAPORE) PTE LTD

Therapeutic

Prescription Only

INJECTION

**Dosage and Administration:** _Dosage:_ As with other general anaesthetic drugs, the individual response to KETAMINE HYDROCHLORIDE INJECTION USP is somewhat varied depending on the dose, route of administration and age of patient, so that the dosage recommended cannot be absolutely fixed. The drug should be titrated against the patient’s requirements. _Onset and duration:_ Because of rapid induction following the initial intravenous injections, the patient should be in a supported position during administration. The onset of action of KETAMINE HYDROCHLORIDE INJECTION USP is rapid and intravenous dose of 2 mg/kg body weight usually produces surgical anaesthesia within 30 seconds after injection, with the anaesthetic effect usually lasting 5 to 10 minutes. lf a longer effect is desired, additional increments can be administered intravenously or intramuscularly to maintain anaesthesia without producing significant cumulative effect. lntramuscular doses from experience (primarily in children, in a range of 9 to 13 mg/kg) usually produce anaesthesia within 3 to 4 minutes following administration, with the anaesthetic effect usually lasting 12 to 25 minutes. _lnduction:_ lntravenous route: The initial dose of KETAMINE HYDROCHLORIDE INJECTION USP administered intravenously may range from 1 mg/kg to 4.5 mg/kg. The average amount required to produce 5 to 10 minutes of surgical anaesthesia has been 2 mg/kg. _Rate of administration:_ lt is recommended that KETAMINE HYDROCHLORIDE INJECTION USP is administered slowly (over a period of 60 seconds). More rapid administration may result in respiratory depression and enhanced pressor response. _Intramuscular route:_ The initial dose of KETAMINE HYDROCHLORIDE INJECTION USP administered intramuscularly ranges from 6.5 to 13 mg/kg. A dose of 10 mg/kg will usually produce 12 to 25 minutes of surgical anaesthesia. _Maintenance of anaesthesia:_ Increments of one half to the full induction dose may be repeated, as needed, for maintenance of anaesthesia. However, it should be noted that purposeless and tonic-clonic movements of extremities may occur during the course of anaesthesia. These movements do not imply a light plane and are not indicative of the need for additional doses of the anaesthetic. lt should be recognized that the larger the total dose of KETAMINE HYDROCHLORIDE INJECTION USP administered, the longer will be the time to complete recovery. _Supplementary agents:_ KETAMINE HYDROCHLORIDE INJECTION USP is clinically compatible with commonly used general and local anaesthetic agents when an adequate respiratory exchange is maintained.