Diltiazem
- Generic Name
- Diltiazem
- Brand Names
- Cardizem, Cartia, Matzim, Taztia, Tiadylt, Tiazac
- Drug Type
- Small Molecule
- Chemical Formula
- C22H26N2O4S
- CAS Number
- 42399-41-7
- Unique Ingredient Identifier
- EE92BBP03H
- Background
Diltiazem is a benzothiazepine derivative with antihypertensive and vasodilating properties. Approved in 1982 by the FDA, it is a member of the non-dihydropyridine calcium channel blockers drug class. It works through various mechanisms of action, but it primarily works by inhibiting the calcium influx into cardiac and vascular smooth muscle during depolariz...
- Indication
Oral
Indicated for the management of hypertension, to lower blood pressure, alone or in combination with other antihypertensive agents.
Indicated for use to improve exercise tolerance in patients with chronic stable angina.
Indicated for the management of variant angina (Prinzmetal's angina).
Intravenous
...
- Associated Conditions
- Angina Pectoris, Variant, Anginal Pain, Atrial Fibrillation, Atrial Flutter, Chronic Stable Angina Pectoris, Dilated Cardiomyopathies, Idiopathic, Fissure;Anal, Hypertension, Paroxysmal Supraventricular Tachycardia (PSVT), Proteinuria, Pulmonary Hypertension (PH), Leg cramps, Prophylaxis of migraine headaches
- Associated Therapies
- -
A Drug-Drug Interaction Study of Diltiazem and MK-1167 in Healthy Adult Participants (MK-1167-006)
- First Posted Date
- 2024-11-25
- Last Posted Date
- 2024-11-25
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 16
- Registration Number
- NCT06703463
- Locations
- 🇺🇸
Celerion (Site 0002), Lincoln, Nebraska, United States
A Clinical Study of MK-4318 and Diltiazem in Healthy People (MK-4318-003)
- First Posted Date
- 2024-11-18
- Last Posted Date
- 2024-11-18
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 19
- Registration Number
- NCT06692647
- Locations
- 🇺🇸
Labcorb CRU, Madison (Site 0001), Madison, Wisconsin, United States
A Study of Diltiazem With a Single Dose of MK-6552 in Healthy Adult Participants (MK-6552-007)
- First Posted Date
- 2024-10-28
- Last Posted Date
- 2024-10-28
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 14
- Registration Number
- NCT06662396
- Locations
- 🇺🇸
ICON (Site 0001), Lenexa, Kansas, United States
Diltiazem in Jervell and Lange-Nielsen Syndrome
- First Posted Date
- 2024-08-02
- Last Posted Date
- 2024-12-19
- Lead Sponsor
- Vanderbilt University Medical Center
- Target Recruit Count
- 1
- Registration Number
- NCT06534671
- Locations
- 🇺🇸
Vanderbilt University Medical Center, Nashville, Tennessee, United States
Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive Coronary Artery Disease
- First Posted Date
- 2022-03-24
- Last Posted Date
- 2022-03-24
- Lead Sponsor
- Charite University, Berlin, Germany
- Target Recruit Count
- 132
- Registration Number
- NCT05294887
- Locations
- 🇨🇭
Universitäres Herzzentrum Zürich, Universitätsspital Zürich, Zürich, Switzerland
🇩🇪Kerckhoff-Klinik gGmbH, Bad Nauheim, Germany
🇩🇪Herz- und Diabeteszentrum NRW, Bad Oeynhausen, Germany
Heart Rate Controller in Computed Tomography Coronary Angiography
- Conditions
- Interventions
- First Posted Date
- 2022-03-02
- Last Posted Date
- 2022-05-17
- Lead Sponsor
- Mahidol University
- Target Recruit Count
- 246
- Registration Number
- NCT05261464
- Locations
- 🇹🇭
Department of Internal Medicine, Faculty of Medicine, Siriraj Hospital Mahidol University, Bangkok, Bangkoknoi, Thailand
A Study to Evaluate the Effect of Co-administration of Itraconazole or Diltiazem on the Single-dose of Danicamtiv in Healthy Participants
- Conditions
- Interventions
- First Posted Date
- 2021-12-17
- Last Posted Date
- 2022-08-10
- Lead Sponsor
- Bristol-Myers Squibb
- Target Recruit Count
- 30
- Registration Number
- NCT05162222
- Locations
- 🇺🇸
Covance Clinical Research Unit - Dallas, Dallas, Texas, United States
Efficacy of Oral Verapamil and Oral Diltiazim on Reduction of Intraoperative Bleeding During Endoscopic Sinus Surgery Under General Anesthesia
- Conditions
- Interventions
- First Posted Date
- 2021-03-10
- Last Posted Date
- 2021-03-10
- Lead Sponsor
- Assiut University
- Target Recruit Count
- 135
- Registration Number
- NCT04790331
Interaction Study of Zanubrutinib With Moderate and Strong CYP3A Inhibitors in Participants With B-Cell Malignancies
- Conditions
- Interventions
- First Posted Date
- 2020-09-16
- Last Posted Date
- 2024-10-26
- Lead Sponsor
- BeiGene
- Target Recruit Count
- 26
- Registration Number
- NCT04551963
- Locations
- 🇦🇺
Concord Repatriation General Hospital, Concord, New South Wales, Australia
🇦🇺John Flynn Private Hospital, Tugun, Queensland, Australia
🇦🇺Royal Adelaide Hospital, Adelaide, South Australia, Australia
Efficacy of Diltiazem for the Control of Blood Pressure in Puerperal Patients With Severe Preeclampsia
- First Posted Date
- 2020-01-10
- Last Posted Date
- 2020-01-10
- Lead Sponsor
- Hospital de la Mujer
- Target Recruit Count
- 42
- Registration Number
- NCT04222855
Drug Development Updates
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