Zidovudine
- Generic Name
- Zidovudine
- Brand Names
- Combivir, Retrovir, Trizivir
- Drug Type
- Small Molecule
- Chemical Formula
- C10H13N5O4
- CAS Number
- 30516-87-1
- Unique Ingredient Identifier
- 4B9XT59T7S
- Background
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse tran...
- Indication
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
- Associated Conditions
- HIV Transmission, Human Immunodeficiency Virus (HIV) Infections, Perinatal HIV transmission
- Associated Therapies
- -
Nucleosides And Darunavir/Dolutegravir In Africa
- First Posted Date
- 2019-06-17
- Last Posted Date
- 2020-07-30
- Lead Sponsor
- Makerere University
- Target Recruit Count
- 465
- Registration Number
- NCT03988452
- Locations
- 🇺🇬
Infectious Diseases Institute, Kampala, Uganda
Study of HIV-Infected and Uninfected Pregnant Woman/Child Dyads in Gaborone, Botswana
- Conditions
- Interventions
- First Posted Date
- 2017-03-23
- Last Posted Date
- 2022-07-20
- Target Recruit Count
- 495
- Registration Number
- NCT03088410
- Locations
- 🇧🇼
Botswana-Harvard AIDS Institute Partnership, Gaborone, Botswana
Belinostat Therapy With Zidovudine for Adult T-Cell Leukemia-Lymphoma
- Conditions
- Interventions
- First Posted Date
- 2016-04-13
- Last Posted Date
- 2024-08-19
- Lead Sponsor
- University of Miami
- Target Recruit Count
- 15
- Registration Number
- NCT02737046
- Locations
- 🇺🇸
University of Miami, Miami, Florida, United States
Antiretroviral Regime for Viral Eradication in Newborns
- Conditions
- Interventions
- First Posted Date
- 2016-03-18
- Last Posted Date
- 2022-09-28
- Target Recruit Count
- 600
- Registration Number
- NCT02712801
- Locations
- 🇨🇳
Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China
🇨🇳Maternal and Child Health Hospital of Guangdong Province, Guangzhou, Guangdong, China
🇨🇳Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China
Latency and Early Neonatal Provision of Antiretroviral Drugs Clinical Trial
- Conditions
- Interventions
- First Posted Date
- 2015-05-01
- Last Posted Date
- 2020-08-04
- Lead Sponsor
- Columbia University
- Target Recruit Count
- 73
- Registration Number
- NCT02431975
- Locations
- 🇿🇦
Rahima Moosa Mother and Child Hospital, Johannesburg, Gauteng, South Africa
Early Infant HIV Treatment in Botswana
- Conditions
- Interventions
- First Posted Date
- 2015-02-24
- Last Posted Date
- 2024-12-19
- Lead Sponsor
- Harvard School of Public Health (HSPH)
- Target Recruit Count
- 67
- Registration Number
- NCT02369406
- Locations
- 🇧🇼
Botswana Harvard HIV/AIDS Institute Partnership, Gaborone, Botswana
Comparison of the Effect of Tipranavir and Ritonavir or Tipranavir and Ritonavir on the Pharmacokinetic Characteristics of Zidovudine in Healthy Volunteers
- Conditions
- Interventions
- First Posted Date
- 2014-09-25
- Last Posted Date
- 2014-09-25
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 60
- Registration Number
- NCT02249416
Chemotherapy for Relapsed Epstein Barr Virus Associated Lymphoma
- First Posted Date
- 2013-10-17
- Last Posted Date
- 2019-09-23
- Lead Sponsor
- University of Miami
- Target Recruit Count
- 6
- Registration Number
- NCT01964755
- Locations
- 🇺🇸
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
🇺🇸University of Miami, Miami, Florida, United States
A Trial to Confirm a Sustained Virological Suppression Defined as HIV-RNA <50 Copies/ml of 3 Different Doses of Fozivudine in Context to a Standard Zidovudine Based Antiretroviral Therapy Regimen
- First Posted Date
- 2012-10-26
- Last Posted Date
- 2018-03-07
- Lead Sponsor
- Michael Hoelscher
- Target Recruit Count
- 120
- Registration Number
- NCT01714414
- Locations
- 🇨🇮
Service des Maladies Infectieuses et Tropicales, CHU de Treichville,, Abidjan, Côte D'Ivoire
🇹🇿NIMR - Mbeya Medical Research Programme,, Mbeya, Tanzania
Economic, Clinical and Quality of Life Assessment in Patients on Antiretroviral Therapy
- First Posted Date
- 2012-09-26
- Last Posted Date
- 2014-11-24
- Lead Sponsor
- Tufts University
- Target Recruit Count
- 68
- Registration Number
- NCT01694017
- Locations
- 🇮🇳
Christian Medical College, Vellore, Tamilnadu, India
Drug Development Updates
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