Zidovudine
- Generic Name
- Zidovudine
- Brand Names
- Combivir, Retrovir, Trizivir
- Drug Type
- Small Molecule
- Chemical Formula
- C10H13N5O4
- CAS Number
- 30516-87-1
- Unique Ingredient Identifier
- 4B9XT59T7S
- Background
A dideoxynucleoside compound in which the 3'-hydroxy group on the sugar moiety has been replaced by an azido group. This modification prevents the formation of phosphodiester linkages which are needed for the completion of nucleic acid chains. The compound is a potent inhibitor of HIV replication, acting as a chain-terminator of viral DNA during reverse tran...
- Indication
Used in combination with other antiretroviral agents for the treatment of human immunovirus (HIV) infections.
- Associated Conditions
- HIV Transmission, Human Immunodeficiency Virus (HIV) Infections, Perinatal HIV transmission
- Associated Therapies
- -
When to Start Anti-HIV Drugs in Children Infected With HIV (The PREDICT Study)
- Conditions
- Interventions
- First Posted Date
- 2005-10-06
- Last Posted Date
- 2013-12-04
- Target Recruit Count
- 300
- Registration Number
- NCT00234091
- Locations
- 🇰🇭
National Pediatric Hosp., Cambodia CIPRA CRS, Phnom Penh, Cambodia
🇰🇭Social Health Clinic, Cambodia CIPRA CRS, Phnom Penh, Cambodia
🇹🇭Prapokklao Hosp. CIPRA CRS, Chantaburi, Thailand
Bortezomib and Antiviral Therapy Followed By Effusion Drainage, Bevacizumab, and Combination Chemotherapy in Treating Patients With Primary Effusion Lymphoma
- Conditions
- First Posted Date
- 2005-09-22
- Last Posted Date
- 2013-06-20
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 15
- Registration Number
- NCT00217503
- Locations
- 🇺🇸
Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office, Bethesda, Maryland, United States
HIV Infection And Metabolic Abnormalities Protocol 1 (HAMA001)
- Conditions
- First Posted Date
- 2005-09-19
- Last Posted Date
- 2012-04-12
- Lead Sponsor
- Kirby Institute
- Target Recruit Count
- 80
- Registration Number
- NCT00192660
- Locations
- 🇦🇺
St. Vincent's Hospital, Sydney, New South Wales, Australia
Open Label Study of NVP+CBV Treatment in Women Who Have Received sdNVP for the pMTCT of HIV
- Conditions
- First Posted Date
- 2005-09-05
- Last Posted Date
- 2013-11-14
- Lead Sponsor
- Boehringer Ingelheim
- Target Recruit Count
- 53
- Registration Number
- NCT00144157
- Locations
- 🇿🇦
Boehringer Ingelheim Investigational Site, Soweto, South Africa
Virological and Clinical Anti-Hepatitis B Virus (HBV) Efficacy of Tenofovir and Emtricitabine in Patients With HIV/HBV co-Infection
- Conditions
- First Posted Date
- 2005-08-09
- Last Posted Date
- 2007-04-24
- Target Recruit Count
- 24
- Registration Number
- NCT00127959
- Locations
- 🇳🇱
Academic Medical Center, Amsterdam, NH, Netherlands
Extended Infant Post-exposure Prophylaxis With Antiretrovirals to Reduce Postnatal HIV Transmission
- Conditions
- Interventions
- First Posted Date
- 2005-06-24
- Last Posted Date
- 2014-03-07
- Lead Sponsor
- Johns Hopkins Bloomberg School of Public Health
- Target Recruit Count
- 3300
- Registration Number
- NCT00115648
- Locations
- 🇲🇼
College of Medicine, Blantyre, Malawi
Reducing the Incidence of Nevirapine Resistance Mutations in Pregnant HIV Infected Women Who Receive Anti-HIV Drugs Prior to and After Giving Birth
- Conditions
- Interventions
- First Posted Date
- 2005-05-02
- Last Posted Date
- 2021-11-05
- Target Recruit Count
- 175
- Registration Number
- NCT00109590
- Locations
- 🇹🇭
Siriraj Hospital Mahidol University CRS, Bangkok, Bangkoknoi, Thailand
🇹🇭Bhumibol Adulyadej Hosp. CRS, Saimai, Bangkok, Thailand
🇹🇭Chiangrai Prachanukroh Hospital CRS, Chiangrai, Thailand
Anti-HIV Drugs for Treating Infants Who Acquired HIV Infection at Birth
- Conditions
- Interventions
- First Posted Date
- 2005-02-07
- Last Posted Date
- 2021-11-02
- Target Recruit Count
- 377
- Registration Number
- NCT00102960
A Comparison of Two Anti-HIV Drug Regimens for Youth Who Have Failed Prior Therapy
- Conditions
- First Posted Date
- 2005-01-26
- Last Posted Date
- 2021-11-01
- Target Recruit Count
- 6
- Registration Number
- NCT00102206
- Locations
- 🇺🇸
Columbia IMPAACT CRS, New York, New York, United States
🇺🇸Chicago Children's CRS, Chicago, Illinois, United States
🇺🇸SUNY Stony Brook NICHD CRS, Stony Brook, New York, United States
Trial of Three Neonatal Antiretroviral Regimens for Prevention of Intrapartum HIV Transmission
- First Posted Date
- 2004-12-13
- Last Posted Date
- 2012-12-04
- Target Recruit Count
- 1735
- Registration Number
- NCT00099359
- Locations
- 🇺🇸
Miller Children's Hospital, Long Beach, California, United States
🇧🇷Hospital Fêmina S.A. Unidade Perinatal de Transmissão Vertical, Porto Alegre, Rio Grande do Sul, Brazil
🇺🇸University of FL, Gainesville, Florida, United States
Drug Development Updates
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