Overview
CXA-10 is under investigation in clinical trial NCT03422510 (FIRSTx - A Study of Oral CXA-10 in Primary Focal Segmental Glomerulosclerosis (FSGS)).
Indication
No indication information available.
Associated Conditions
No associated conditions information available.
Research Report
CXA-10 (10-Nitrooleic Acid): A Comprehensive Pharmacological and Developmental Review of a Novel Endogenous Signaling Modulator
Executive Summary
CXA-10, known chemically as 10-Nitrooleic acid, is an investigational small molecule drug belonging to the class of nitro fatty acids (NFAs). It is an endogenous signaling molecule formed in the body under conditions of inflammation and nitrative stress.[1] The therapeutic rationale for CXA-10 was built upon a compelling and pleiotropic mechanism of action, positioning it as a potential treatment for a range of complex diseases characterized by oxidative stress, inflammation, and fibrosis.[3]
The primary mechanism of CXA-10 involves its function as an electrophilic signaling mediator. It modulates multiple fundamental cellular pathways, most notably through the potent activation of the cytoprotective Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway and the concurrent inhibition of the pro-inflammatory Nuclear Factor-kappa B (NF-κB) signaling cascade.[2] This dual action, which simultaneously enhances endogenous defense mechanisms while suppressing inflammatory damage, was supported by a robust body of preclinical evidence across various animal models of renal, cardiopulmonary, and metabolic diseases.
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
---|---|---|---|---|---|
2019/10/14 | Phase 2 | Terminated | Gladwin, Mark, MD | ||
2019/08/12 | Phase 2 | Terminated | |||
2018/12/03 | Phase 2 | Recruiting | |||
2018/09/21 | Phase 2 | Withdrawn | Sally E. Wenzel MD | ||
2018/02/28 | Phase 2 | Terminated | |||
2018/02/05 | Phase 2 | Completed | |||
2015/09/11 | Phase 1 | Completed | |||
2015/06/02 | Phase 1 | Completed | |||
2014/12/09 | Phase 1 | Completed | |||
2014/09/25 | Phase 1 | Completed |
FDA Drug Approvals
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No FDA approvals found for this drug. |
EMA Drug Approvals
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No EMA approvals found for this drug. |
HSA Drug Approvals
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No HSA approvals found for this drug. |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
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No NMPA approvals found for this drug. |
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
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No PPB approvals found for this drug. |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
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No TGA approvals found for this drug. |
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
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No Health Canada approvals found for this drug. |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
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No CIMA AEMPS (Spain) approvals found for this drug. |
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
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No Philippines FDA approvals found for this drug. |
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
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No Saudi SFDA approvals found for this drug. |
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
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No Malaysia NPRA approvals found for this drug. |
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
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No UK EMC drug information found for this drug. |
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