Calcifediol
- Generic Name
- Calcifediol
- Brand Names
- Rayaldee
- Drug Type
- Small Molecule
- Chemical Formula
- C27H44O2
- CAS Number
- 19356-17-3
- Unique Ingredient Identifier
- T0WXW8F54E
- Background
The major circulating metabolite of vitamin D3 (cholecalciferol). It is produced in the liver and is the best indicator of the body's vitamin D stores. It is effective in the treatment of rickets and osteomalacia, both in azotemic and non-azotemic patients. Calcifediol also has mineralizing properties.
- Indication
Used to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or...
- Associated Conditions
- Secondary Hyperparathyroidism (SHPT)
- Associated Therapies
- -
Calcifediol in the Treatment of SARS-CoV-2 Disease (COVID-19).
- First Posted Date
- 2024-02-28
- Last Posted Date
- 2024-02-28
- Lead Sponsor
- Complejo Hospitalario Universitario de Albacete
- Target Recruit Count
- 275
- Registration Number
- NCT06279910
- Locations
- 🇪🇸
Complejo Hospitalario Universitario de la Gerencia de Atención Integrada (GAI) de Albacete, Albacete, Spain
🇪🇸Maimónides Biomedical Research Institute of Córdoba (IMIBIC)., Cordoba, Spain
Calcifediol in the Treatment of COVID 19
- First Posted Date
- 2023-04-19
- Last Posted Date
- 2023-04-28
- Target Recruit Count
- 728
- Registration Number
- NCT05819918
- Locations
- 🇪🇸
Hospital Universitario Reina Sofia, Cordoba, Córdoba, Spain
Safety and Efficacy of Rayaldee for Treating Mild to Moderate COVID-19
- Conditions
- Interventions
- First Posted Date
- 2020-09-16
- Last Posted Date
- 2024-05-28
- Lead Sponsor
- OPKO Health, Inc.
- Target Recruit Count
- 171
- Registration Number
- NCT04551911
- Locations
- 🇺🇸
OPKO Investigative Site, Omaha, Nebraska, United States
25-Hydroxyvitamin D Pharmacokinetic Study
- Conditions
- Interventions
- First Posted Date
- 2018-01-17
- Last Posted Date
- 2020-06-04
- Lead Sponsor
- Boston University
- Target Recruit Count
- 16
- Registration Number
- NCT03401541
- Locations
- 🇺🇸
Solomon Carter Fuller Mental Health Center, Boston, Massachusetts, United States
Activated Vitamin D for the Prevention and Treatment of Acute Kidney Injury
- Conditions
- Interventions
- First Posted Date
- 2016-11-11
- Last Posted Date
- 2022-02-03
- Lead Sponsor
- David Leaf
- Target Recruit Count
- 150
- Registration Number
- NCT02962102
- Locations
- 🇺🇸
Brigham and Women's Hospital, Boston, Massachusetts, United States
Efficacy of Calcifediol Supplementation in Asthma Control in Asthmatic Patients With Vitamin D Deficiency (ACViD)
- First Posted Date
- 2016-06-20
- Last Posted Date
- 2017-06-16
- Lead Sponsor
- MurciaSalud
- Target Recruit Count
- 112
- Registration Number
- NCT02805907
- Locations
- 🇪🇸
Servicio Murciano de Salud, Murcia, Spain
Effect of Vitamin D on Ventricular Remodeling in Patients With Acute Myocardial Infarction (VITDAMI)
- First Posted Date
- 2015-09-14
- Last Posted Date
- 2023-10-03
- Target Recruit Count
- 109
- Registration Number
- NCT02548364
- Locations
- 🇪🇸
Hospital Puerta de Hierro, Majadahonda, Madrid, Spain
🇪🇸Hospital Rey Juan Carlos, Mostoles, Madrid, Spain
🇪🇸Hospital de Fuenlabrada, Fuenlabrada, Madrid, Spain
Efficacy and Safety of Paricalcitol in the Reduction of Secondary Hyperparathyroidism After Kidney Transplantation.
- Conditions
- Interventions
- First Posted Date
- 2013-09-11
- Last Posted Date
- 2018-11-19
- Lead Sponsor
- Fundación Senefro
- Target Recruit Count
- 148
- Registration Number
- NCT01939977
- Locations
- 🇪🇸
Hospital Universitari Germans Trias I Pujol de Badalona, Badalona, Barcelona, Spain
🇪🇸Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain
🇪🇸Hospital Puerta Del Mar, Cádiz, Spain
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.