SN-38
- Generic Name
- SN-38
- Brand Names
- Trodelvy
- Drug Type
- Small Molecule
- Chemical Formula
- C22H20N2O5
- CAS Number
- 86639-52-3
- Unique Ingredient Identifier
- 0H43101T0J
Overview
7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan Irinotecan, a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative Breast Cancer, among others.
Background
7-ethyl-10-hydroxycamptothecin (SN 38) is a liposomal formulation of the active metabolite of Irinotecan Irinotecan, a chemotherapeutic pro-drug approved for the treatment of advanced colorectal cancer. SN 38 has been used in trials studying the treatment of Cancer, Advanced Solid Tumors, Small Cell Lung Cancer, Metastatic Colorectal Cancer, and Triple Negative Breast Cancer, among others.
Indication
Investigated for use/treatment in colorectal cancer.
Associated Conditions
- Hormone Receptor Positive Metastatic Breast Cancer
- Locally Advanced or Metastatic Urothelial Carcinoma (UC)
- Metastatic Triple Negative Breast Cancers
- Unresectable Triple-Negative Breast Carcinoma
- Metastatic HR Positive, HER2/Neu Negative Breast Cancer
- Unresectable Locally Advanced Triple-negative Breast Cancer
- Unresectable, locally advanced HR Positive, HER2/Neu Negative Breast Cancer
- Unresectable, locally advanced Hormone Receptor Positive Breast Carcinoma
Clinical Trials
FDA Approved Products
Singapore Approved Products
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