Ceftriaxone

Generic Name: Ceftriaxone

Brand Names: Rocephin

Drug Type: Small Molecule

Chemical Formula: C_₁₈H_₁₈N_₈O_₇S_₃

CAS Number: 73384-59-5

Unique Ingredient Identifier: 75J73V1629

Background: Ceftriaxone is a broad-spectrum third-generation cephalosporin antibiotic. It has a very long half-life compared to other cephalosporins and is high penetrable into the meninges, eyes, and inner ear. Ceftriaxone has broader and stronger gram-negative coverage then first or second-generation cephalosporins, but worse activity against methicillin-susceptible S...

Indication: Ceftriaxone is used for the treatment of the infections (respiratory, skin, soft tissue, UTI, ENT) caused by susceptible organisms. Organisms that are generally susceptible to ceftriaxone include S. pneumoniae, S. pyogenes (group A beta-hemolytic streptococci), coagulase-negative staphylococci, Some Enterobacter spp, H. influenzae, N. gonorrhoeae, P. mirabil...

Associated Conditions: Abscess Brain, Bacterial Endocarditis, Bacterial Infections, Bacterial Sinusitis, Bone and Joint Infections, Chancroid, Community Acquired Pneumonia (CAP), Conjunctivitis gonococcal neonatal, Epididymitis, Epiglottitis, Gonococcal arthritis, Gonococcal infection of pharynx, Gonococcal pelvic inflammatory disease, Intraabdominal Infections, Lower respiratory tract infection bacterial, Lyme Neuroborreliosis, Meningitis, Bacterial, Ophthalmia neonatorum due to gonococcus, Postoperative Infections, Prosthetic Joint Infections, Sepsis Bacterial, Septic Arthritis, Shigellosis, Skin and Subcutaneous Tissue Bacterial Infections, Syphilis, Vulvovaginitis gonococcal, Whipple Disease, Bacterial otitis media, Complicated Urinary Tract Infection caused by susceptible bacteria, Disease caused by Salmonella typhi, Susceptible Bacterial Infections, Uncomplicated Gonorrhea, Uncomplicated Urinary tract infection bacterial

Associated Therapies: -

Clinical Trials

Antibiotic Prophylaxis for Transrectal Prostate Biopsy

Phase 4

Completed

Conditions: Infection

Interventions: Drug: trimethoprim-sulfamethoxazole
Drug: Ciprofloxacin
Drug: cefuroxime
Drug: ceftriaxone
Drug: gentamicin
Drug: amikacin
Drug: aztreonam
Drug: imipenem

First Posted Date: 2012-08-08

Last Posted Date: 2019-06-25

Lead Sponsor: Northwestern University

Target Recruit Count: 563

Registration Number: NCT01659866

Locations: 🇺🇸
Northwestern University Department of Urology, Chicago, Illinois, United States

Study of Lyme Neuroborreliosis

Phase 4

Completed

Conditions: Lyme Neuroborreliosis

Interventions: Drug: Doxycycline
Drug: Ceftriaxone

First Posted Date: 2012-07-09

Last Posted Date: 2019-05-13

Lead Sponsor: Turku University Hospital

Target Recruit Count: 210

Registration Number: NCT01635530

Locations: 🇫🇮
Turku University Hospital, Turku, Finland
🇫🇮
Helsinki University Hospital, Helsinki, Finland

Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Community Acquired Bacterial Pneumonia (CABP)

Phase 2

Completed

Conditions: Community Acquired Pneumonia
Infections

Interventions: Drug: Ceftriaxone
Drug: Ceftaroline fosamil
Drug: amoxicillin clavulanate

First Posted Date: 2012-02-10

Last Posted Date: 2015-01-13

Lead Sponsor: Forest Laboratories

Target Recruit Count: 161

Registration Number: NCT01530763

Locations: 🇺🇦
Investigational Site, Zaporizhia, Ukraine
🇬🇪
Investigational Site2, Tbilisi, Georgia
🇬🇪
Investigational Site3, Tbilisi, Georgia

A Phase 3 Study Of Intravenous Metronidazole For Intrabdominal Infection

Phase 3

Completed

Conditions: Intra-abdominal Infections

Interventions: Drug: Metronidazole
Drug: Ceftriaxone sodium

First Posted Date: 2011-11-17

Last Posted Date: 2014-01-24

Lead Sponsor: Pfizer

Target Recruit Count: 38

Registration Number: NCT01473836

Locations: 🇯🇵
Iida Municipal Hospital, Iida, Nagano, Japan
🇯🇵
National Hospital Organization Kokura Medical Center, Kitakyushu, Fukuoka, Japan
🇯🇵
Koshigaya Municipal Hospital, Koshigaya, Saitama, Japan

and more 12 locations