Sugammadex
- Generic Name
- Sugammadex
- Brand Names
- Bridion, Sugammadex Adroiq, Sugammadex Amomed, Sugammadex Fresenius Kabi, Sugammadex Mylan, Sugammadex Piramal
- Drug Type
- Small Molecule
- Chemical Formula
- C72H112O48S8
- CAS Number
- 343306-71-8
- Unique Ingredient Identifier
- 361LPM2T56
- Background
Sugammadex is a selective relaxant binding agent indicated for reversal of neuromuscular blockade induced by rocuronium bromide and vecuronium bromide during surgery. Rocuronium bromide and vecuronium bromide are neuromuscular blocking medications that cause temporary paralysis and are especially useful for general anesthesia, ventilation, or tracheal intubation that patients may require for surgery. Sugammadex provides a new treatment option to reverse the effects of those medications and possibly help patients recover sooner post-surgery. Sugammadex (brand name Bridion) is marketed by Merck Sharp and Dohme, and was approved by the United States FDA on December 15, 2015.
- Indication
Sugammadex is indicated for the reversal of neuromuscular blockade induced by rocuronium bromide or vecuronium bromide in adults and pediatric patients ≥2 years old who are undergoing surgery.
- Associated Conditions
- Neuromuscular blockade caused by vecuronium bromide
- Associated Therapies
- -
Reversal With Low Doses of Sugammadex in Patients Undergoing Non-cardiac Surgery
- Conditions
- Postoperative Residual CurarizationNeuromuscular Block
- Interventions
- First Posted Date
- 2018-03-09
- Last Posted Date
- 2018-05-30
- Lead Sponsor
- The Hospital of Vestfold
- Target Recruit Count
- 144
- Registration Number
- NCT03460509
Designing Optimal Prevention and Management of Postoperative Nausea and Emesis for Patients Undergoing Laparoscopic Sleeve Gastrectomy
- Conditions
- Post-operative Nausea and VomitingLaparoscopic Sleeve Gastrectomy
- Interventions
- First Posted Date
- 2018-02-15
- Last Posted Date
- 2024-02-14
- Lead Sponsor
- Stony Brook University
- Target Recruit Count
- 83
- Registration Number
- NCT03435003
- Locations
- 🇺🇸
Stony Brook University Hospital, Stony Brook, New York, United States
Deep Neuromuscular Block During General Anaesthesia in Robotic Surgery
- Conditions
- Complication of Ventilation TherapyObservation of Neuromuscular BlockPostoperative Recovery
- Interventions
- First Posted Date
- 2018-02-05
- Last Posted Date
- 2018-02-05
- Lead Sponsor
- University Hospital Olomouc
- Target Recruit Count
- 138
- Registration Number
- NCT03420937
- Locations
- 🇨🇿
Dept. of Anesthesiology and Intensive Care Medicine, University Hospital Olomouc, Olomouc, Czechia
The Effect of Sugammadex Given Based on Ideal, Actual or Adjusted Body Weight on Reversal of Rocuronium.
- First Posted Date
- 2017-12-21
- Last Posted Date
- 2017-12-21
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 60
- Registration Number
- NCT03381209
- Locations
- 🇪🇬
Faculty of Medicine, Ain Shams University, Cairo, Egypt
Effect of NMBA on Surgical Conditions in THR
- Conditions
- SurgeryPostoperative Pain
- Interventions
- First Posted Date
- 2017-12-12
- Last Posted Date
- 2019-03-12
- Lead Sponsor
- Algemeen Ziekenhuis Maria Middelares
- Registration Number
- NCT03369782
- Locations
- 🇧🇪
AZ Maria Middelares, Gent, Oost-Vlaanderen, Belgium
Combined Use of Low-dose Sugammadex Plus Neostigmine Administered for Reversal of Rocuronium
- Conditions
- Incidence of Postoperative Residual Curarization
- Interventions
- First Posted Date
- 2017-11-01
- Last Posted Date
- 2017-11-01
- Lead Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
- Target Recruit Count
- 90
- Registration Number
- NCT03328312
Sugammadex Versus Neostigmine for Reversal of Rocuronium Neuromuscular
- Conditions
- AnesthesiaNeuromuscular Blockade
- Interventions
- First Posted Date
- 2017-10-26
- Last Posted Date
- 2021-11-16
- Lead Sponsor
- The Cleveland Clinic
- Target Recruit Count
- 69
- Registration Number
- NCT03322657
- Locations
- 🇺🇸
Cleveland Clinic, Cleveland, Ohio, United States
Monitoring of Postoperative Residual Neuromuscular Blockade in Laparoscopic Surgery
- Conditions
- Neuromuscular Block, Residual
- Interventions
- First Posted Date
- 2017-09-26
- Last Posted Date
- 2018-10-09
- Lead Sponsor
- Seoul National University Bundang Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT03292965
- Locations
- 🇰🇷
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of
A Study to Compare Neostigmine vs Sugammadex in Length of PACU Stay in Patients Undergoing Sleeve Gastrectomy Surgery
- Conditions
- Postoperative Nausea and VomitingRespiratory Conditions Due to Other External Agents
- Interventions
- First Posted Date
- 2017-09-08
- Last Posted Date
- 2019-05-28
- Lead Sponsor
- Virtua Health, Inc.
- Target Recruit Count
- 68
- Registration Number
- NCT03276026
- Locations
- 🇺🇸
Virtua Memorial Hospital, Mount Holly, New Jersey, United States
GA/Spinal vs. GA/Spinal/NMB for Operative Repair of Hip Fracture
- Conditions
- Hip FracturesNeuromuscular BlockadeAnesthesia, SpinalAnesthesia, General
- Interventions
- First Posted Date
- 2017-07-21
- Last Posted Date
- 2019-08-20
- Lead Sponsor
- Loyola University
- Registration Number
- NCT03226080
- Locations
- 🇺🇸
Loyola University Medical Center, Maywood, Illinois, United States
Drug Development Updates
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