Overview
An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106) The FDA has withdrawn all oral drug products containing chloramphenicol, due to the high risk of fatal aplastic anemia associated with this specific route of administration.
Indication
Used in treatment of cholera, as it destroys the vibrios and decreases the diarrhea. It is effective against tetracycline-resistant vibrios. It is also used in eye drops or ointment to treat bacterial conjunctivitis.
Associated Conditions
- Acne
- Allergic Conjunctivitis (AC)
- Bacterial Conjunctivitis
- Bacterial Conjunctivitis caused by susceptible bacteria
- Bacterial Infections
- Bacterial Keratitis
- Bacterial dacryocystitis
- Bacterial diarrhoea
- Keratitis
- Ocular Inflammation
- Trachoma
- Anterior eye segment inflammation
- Bacterial blepharitis
- Bacterial corneal ulcers
- Non-purulent ophthalmic infections caused by susceptible bacteria
- Superficial ocular infections
- Swelling of the eyes
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|
No clinical trials found
No clinical trials found for this drug
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Bestmade Natural Products | 82969-2064 | ORAL | 200 [hp_C] in 200 [hp_C] | 1/30/2025 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| CHLORAMPHENICOL EAR DROPS 5% w/v | SIN04574P | SOLUTION | 5% | 6/2/1990 | |
| XEPANICOL EYE DROPS 0.5% | SIN00231P | SOLUTION | 5MG/ML | 4/5/1988 | |
| OPTICHLOR EYE DROPS | SIN13054P | SOLUTION, STERILE | 5.0 mg/ml | 3/9/2005 | |
| CHLORAMPHENICOL EAR DROPS 5% w/v | SIN00230P | SOLUTION | 5% | 4/5/1988 | |
| OFTALMOLOSA CUSI CHLORAMPHENICOL EYE OINTMENT 1% | SIN06023P | OINTMENT | 10 mg/g | 6/3/1991 |
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| VANAFEN OPHTHALMIC OINTMENT 1% W/W | N/A | N/A | N/A | 12/19/2012 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| AMCAL Chloramphenicol 5 mg/mL (0.5 %) Eye Drops bottle | 338569 | Medicine | A | 6/29/2020 | |
| Minims Chloramphenicol 0.5% 5mg/mL eye drops tube | 32263 | Medicine | A | 10/30/1991 | |
| CHLORSIG 1% chloramphenicol 10 mg/g eye ointment tube | 19662 | Medicine | A | 10/14/1991 | |
| CHLORAMPHENICOL GPPL chloramphenicol 5 mg/mL eyedrops bottle | 222778 | Medicine | A | 4/24/2014 | |
| OCUZO EYE OINTMENT chloramphenicol 10 mg/g tube | 450127 | Medicine | A | 5/29/2024 | |
| CHEMISTS' OWN CLORAH chloramphenicol 5 mg/mL eyedrops bottle | 222549 | Medicine | A | 4/15/2014 | |
| PRICELINE PHARMACY CHLORAMPHENICOL EYE DROPS chloramphenicol 5 mg/mL bottle | 330168 | Medicine | A | 2/19/2020 | |
| TERRYWHITE CHEMMART CHLORAMPHENICOL EYE DROPS chloramphenicol 5 mg/mL bottle | 330169 | Medicine | A | 2/19/2020 | |
| NEO-CHLOR chloramphenicol 5 mg/mL eye drops bottle | 474090 | Medicine | A | 12/19/2024 | |
| CHLORAMPHENICOL AH chloramphenicol 5 mg/mL eyedrops bottle | 222546 | Medicine | A | 4/15/2014 |
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| CHLOROMYCETIN OPH SOLN 0.5% | parke-davis division, warner-lambert canada inc. | 00221678 | Liquid - Ophthalmic | .5 % | 12/31/1971 |
| SOPAMYCETIN/HC SUSP | laboratoires charton laboratories | 00438669 | Drops - Ophthalmic | .2 % | 12/31/1988 |
| PENTAMYCETIN/HC | 01980572 | Suspension - Otic
,
Ophthalmic | 2 MG / ML | 12/31/1992 | |
| PMS-CHLORAMPHENICOL OPHTHALMIC SOLN 0.5% | 00861383 | Drops - Ophthalmic | .5 % | 12/31/1992 | |
| ELASE CHLOROMYCETIN ONT | parke-davis division, warner-lambert canada inc. | 00156124 | Ointment - Topical
,
Vaginal | 10 MG / G | 12/31/1962 |
| MINIMS CHLORAMPHENICOL 0.5% | chauvin pharmaceuticals limited | 02148374 | Drops - Topical
,
Ophthalmic | .5 % | 12/31/1995 |
| NOVO-CHLOROCAP CAP 250MG | novopharm limited | 00020907 | Capsule - Oral | 250 MG / CAP | 12/31/1966 |
| CHLORAMPHENICOL | pharma stulln inc. | 02023857 | Solution - Ophthalmic | 0.5 % | 12/31/1994 |
| ACTINAC PWR | roussel canada inc. | 00429090 | Powder - Topical | 40 MG / G | 12/31/1978 |
| SOPAMYCETIN SOLN OTIQUE 5% | laboratoires charton laboratories | 00717932 | Drops - Otic | 5 % | 12/31/1988 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| CORTISON CHEMICETINA 25mg/g + 20mg/g POMADA | Teofarma S.R.L. | 26231 | POMADA | Medicamento Sujeto A Prescripción Médica | Commercialized |
| CORTISON CHEMICETINA POMADA 5mg/g + 10mg/g POMADA | Teofarma S.R.L. | 26230 | POMADA | Medicamento Sujeto A Prescripción Médica | Commercialized |
| OFTALMOLOSA CUSI DE ICOL POMADA OFTALMICA | Fidia Farmaceutici S.P.A. | 40356 | POMADA OFTÁLMICA | Medicamento Sujeto A Prescripción Médica | Commercialized |
| OFTALMOLOSA CUSI CLORAMFENICOL 10 MG/G POMADA OFTÁLMICA | 19495 | POMADA OFTÁLMICA | Medicamento Sujeto A Prescripción Médica | Commercialized |
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
Help Us Improve
Your feedback helps us provide better drug information and insights.