Oxybuprocaine
- Generic Name
- Oxybuprocaine
- Brand Names
- Altafluor, Fluress
- Drug Type
- Small Molecule
- Chemical Formula
- C17H28N2O3
- CAS Number
- 99-43-4
- Unique Ingredient Identifier
- AXQ0JYM303
- Background
Oxybuprocaine (also known as Benoxinate) is a local anesthetic, which is used especially in ophthalmology and otolaryngology. Oxybuprocaine binds to sodium channels and reversibly stabilizes the neuronal membrane which decreases its permeability to sodium ions.
- Indication
Used to temporarily numb the front surface of the eye so that the eye pressure can be measured or a foreign body removed.
- Associated Therapies
- Local Anesthesia of the Mouth
Effect of Benoxinate Hydrochloride Eye Drops on The Premature Infant Pain Profile Score During Retinopathy of Prematurity Screening
- Conditions
- Retinopathy of Prematurity
- Interventions
- Drug: artificial tear (Sodium Hyaluronate 2 mg/ml) eye drops.
- First Posted Date
- 2024-06-17
- Last Posted Date
- 2024-06-17
- Lead Sponsor
- Alexandria University
- Target Recruit Count
- 88
- Registration Number
- NCT06461975
- Locations
- 🇪🇬
Faculty of Medicine Alexandria University, Alexandria, Egypt
Efficacy and Safety of Chloroprocaine 3% Gel and Oxybuprocaine 0.4% Eye Drops Anesthesia in Pediatric Population
- Conditions
- Local Anesthetic
- Interventions
- First Posted Date
- 2023-07-03
- Last Posted Date
- 2025-03-18
- Lead Sponsor
- Sintetica SA
- Target Recruit Count
- 74
- Registration Number
- NCT05926258
- Locations
- 🇮🇹
IRCCS Ospedale San Raffaele, Milano, MI, Italy
🇮🇹Ospedale della Donna e del Bambino, Ospedale Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona, VR, Italy
🇮🇹ASST Grande Ospedale Metropolitano Niguarda, Milano, MI, Italy
Hemodynamic Response to Pain During Retinopathy Of Prematurity Screening
- Conditions
- Preterm
- Interventions
- Drug: saline 0.9% .
- First Posted Date
- 2022-12-27
- Last Posted Date
- 2025-03-25
- Lead Sponsor
- Alexandria University
- Target Recruit Count
- 68
- Registration Number
- NCT05666362
- Locations
- 🇪🇬
Marwa Mohamed Farag, Alexandria, Egypt
Optimization of Sampling and Processing of Samples for Molecular Microbial Research on Ocular Surface Samples
- Conditions
- MicrobiotaOcular Surface
- Interventions
- Diagnostic Test: Conjunctival swabDrug: artificial tears
- First Posted Date
- 2019-12-10
- Last Posted Date
- 2022-07-22
- Lead Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Target Recruit Count
- 24
- Registration Number
- NCT04193774
- Locations
- 🇧🇪
University Hospitals Leuven, Department of Ophthalmology, Leuven, Belgium
Conscious Sedation for Cataract Operations Under Topical Anaesthesia
- Conditions
- Conscious Sedation
- Interventions
- First Posted Date
- 2019-05-01
- Last Posted Date
- 2021-01-08
- Lead Sponsor
- Menoufia University
- Target Recruit Count
- 100
- Registration Number
- NCT03933280
- Locations
- 🇪🇬
Faculty of Medicine, Cairo, Shebin El-kom, Egypt
VisuMax Femtosecond Laser Small Incision Lenticule Extraction for the Correction of High Myopia
- Conditions
- MyopiaRefractive Errors
- Interventions
- Procedure: Small incision lenticule extraction
- First Posted Date
- 2015-08-19
- Last Posted Date
- 2024-04-23
- Lead Sponsor
- London Vision Clinic
- Target Recruit Count
- 114
- Registration Number
- NCT02528123
- Locations
- 🇬🇧
London Vision Clinic, London, United Kingdom
Efficacy of BNX Sublingual Tablets Versus BNX Sublingual Film for Treatment of Opioid-Dependent Adults
- Conditions
- Opioid Dependence, on Agonist Therapy
- Interventions
- First Posted Date
- 2013-07-26
- Last Posted Date
- 2017-05-10
- Lead Sponsor
- Orexo AB
- Target Recruit Count
- 759
- Registration Number
- NCT01908842
Drug Development Updates
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