Diacerein
- Generic Name
- Diacerein
- Brand Names
- -
- Drug Type
- Small Molecule
- Chemical Formula
- C19H12O8
- CAS Number
- 13739-02-1
- Unique Ingredient Identifier
- 4HU6J11EL5
- Background
Diacerein is a prodrug which is metabolized to rhein. It is currently approved in France for the treatment of osteoarthritis although the use of diacerein is restricted due to the side effects including severe diarrhea . Diacerein is under investigation for the treatment of Insulin Resistance, Diabetes Mellitus (Type 2), and Diabetes-Related Complications.
- Indication
For the treatment of osteoarthritis affecting the hip or knee .
- Associated Conditions
- Osteoarthritis in the Hip Joint, Osteoarthritis of the Knee
- Associated Therapies
- -
Safety and Efficacy of the Combination of Diacerein 100 mg Daily and MTX Versus MTX Alone in the Treatment of Early Rheumatoid Arthritis (RA)
- First Posted Date
- 2010-12-21
- Last Posted Date
- 2015-11-05
- Lead Sponsor
- TRB Chemedica
- Target Recruit Count
- 40
- Registration Number
- NCT01264211
- Locations
- 🇹🇭
Juree Rawdmanee, Sukhumvit, Bangkok, Thailand
🇹🇭Faculty of medicine, Chiangmai University, Chiangmai, Thailand
Diacerein as Adjuvant to Diclofenac Sodium in Indian Patients of Osteoarthritis (OA) Knee
- First Posted Date
- 2010-05-10
- Last Posted Date
- 2010-05-31
- Lead Sponsor
- Government Medical College, Amritsar
- Target Recruit Count
- 84
- Registration Number
- NCT01120015
- Locations
- 🇮🇳
Kuljinder Singh, Amritsar, Punjab, India
Effect of Diacerein on Hand Osteoarthritis
- First Posted Date
- 2008-05-28
- Last Posted Date
- 2010-12-03
- Lead Sponsor
- Seoul National University Hospital
- Target Recruit Count
- 86
- Registration Number
- NCT00685542
- Locations
- 🇰🇷
Seoul National University Hospital, Seoul, Korea, Republic of
Chondromodulating Effect of Diacerein in Osteoarthritis of the Hip
- Conditions
- Hip Osteoarthritis
- First Posted Date
- 2007-03-23
- Last Posted Date
- 2008-07-25
- Lead Sponsor
- Laboratoires NEGMA
- Target Recruit Count
- 500
- Registration Number
- NCT00451360
- Locations
- 🇫🇷
Hôpital Nord, Amiens, France
🇫🇷Hôpital Ambroise Paré, Boulogne, France
🇫🇷CH Lyon Sud, Pierre Bénite, France
Symptomatic Efficacy of Diacerein in Knee Osteoarthritis
- Conditions
- Knee Osteoarthritis
- First Posted Date
- 2007-03-08
- Last Posted Date
- 2010-03-04
- Lead Sponsor
- Laboratoires NEGMA
- Target Recruit Count
- 500
- Registration Number
- NCT00445276
- Locations
- 🇫🇷
Chu Trousseau, Tours, France
Drug Development Updates
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