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Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include RdmB, modification methylase TaqI, rRNA (adenine-N6-)-methyltransferase, and modification methylase RsrI.
Sinefungin is a solid. This compound belongs to the purine nucleosides and analogues. These are compounds comprising a purine base attached to a sugar. The proteins that adenosyl-ornithine target include RdmB, modification methylase TaqI, rRNA (adenine-N6-)-methyltransferase, and modification methylase RsrI.
Sinefungin is a structural analog of S-adenosylmethionine (SAM) that acts as a competitive inhibitor of LuxI-type acyl-homoserine lactone (AHL) synthases, the enzymes that produce AHL quorum-sensing autoinducers. By competing at the synthase level it specifically attenuates quorum-sensing signaling molecule production without affecting cellular SAM biosynthesis or concentration, thereby disrupting bacterial cell-to-cell communication and suppressing virulence factor expression rather than killing the bacteria directly (quorum sensing inhibitor/anti-virulence mechanism).
每项发明一条，涵盖美国、欧洲、PCT 与中国的同族专利。
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专利文献通常使用化学名或研发代号指代药物，而非通用名；且专利申请在提交约 18 个月后才公开，较新的药物可能尚未出现在这里。
