Epicatechin

• A large-scale COSMOS randomized clinical trial involving 21,442 older adults found that cocoa extract supplementation did not significantly reduce the overall occurrence or progression of age-related macular degeneration over a 3.6-year period. • Researchers observed a potential 23% decreased risk of AMD events during the first two years of cocoa extract treatment (HR, 0.77; 95% CI, 0.59-1.01), but no additional benefits were seen beyond this timeframe. • The study, led by William G. Christen from Brigham and Women's Hospital and Harvard Medical School, suggests further research is needed to clarify whether cocoa extract supplementation may provide short-term protective effects against AMD.