Chlorambucil
- Generic Name
- Chlorambucil
- Brand Names
- Leukeran
- Drug Type
- Small Molecule
- Chemical Formula
- C14H19Cl2NO2
- CAS Number
- 305-03-3
- Unique Ingredient Identifier
- 18D0SL7309
- Background
A nitrogen mustard alkylating agent used as antineoplastic agent for the treatment of various malignant and nonmalignant diseases. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
- Indication
For treatment of chronic lymphatic (lymphocytic) leukemia, childhood minimal-change nephrotic syndrome, and malignant lymphomas including lymphosarcoma, giant follicular lymphoma, Hodgkin's disease, non-Hodgkin's lymphomas, and Waldenström’s Macroglobulinemia.
- Associated Conditions
- Chronic Lymphocytic Leukemia, Hodgkins Disease (HD), Indolent Lymphoma, Lymphoma, Lymphoma, Diffuse, MALT Lymphoma, Mantle Cell Lymphoma (MCL), Nephrotic syndrome with lesion of minimal change glomerulonephritis, Non-Hodgkin's Lymphoma (NHL), Waldenström's Macroglobulinemia (WM), Giant follicular lymphoma
- Associated Therapies
- -
Radiation Therapy or Combination Chemotherapy in Treating Young Patients With Hodgkin's Lymphoma
- Conditions
- First Posted Date
- 2006-12-28
- Last Posted Date
- 2013-08-02
- Lead Sponsor
- Children's Cancer and Leukaemia Group
- Target Recruit Count
- 353
- Registration Number
- NCT00416377
Treatment of Mantle Cell Lymphoma at Diagnosis for Patients Under 65 Years
- First Posted Date
- 2006-02-02
- Last Posted Date
- 2009-02-12
- Lead Sponsor
- French Innovative Leukemia Organisation
- Target Recruit Count
- 39
- Registration Number
- NCT00285389
- Locations
- 🇫🇷
Regional university hospital, Rennes, France
🇫🇷REgional Hospital, Tours, France
Fludarabine or Chlorambucil as First-Line Therapy in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia
- Conditions
- Interventions
- First Posted Date
- 2005-12-07
- Last Posted Date
- 2019-05-23
- Lead Sponsor
- German CLL Study Group
- Target Recruit Count
- 206
- Registration Number
- NCT00262795
- Locations
- 🇩🇪
Onkologische Schwerpunktpraxis, Cottbus, Germany
🇦🇹Hanuschkrankenhaus, Vienna, Austria
🇩🇪Saint Josef - Hospital Bochum, Bochum, Germany
Safety and Efficacy of SDX-101 (R-Etodolac) in Combination With Chlorambucil, and That of Chlorambucil Alone, in Patients With Chronic Lymphocytic Leukemia (CLL)
- Conditions
- Interventions
- First Posted Date
- 2005-09-09
- Last Posted Date
- 2012-06-11
- Lead Sponsor
- Cephalon
- Target Recruit Count
- 88
- Registration Number
- NCT00151736
- Locations
- 🇫🇷
Service maladies du sang CHRU- rue Michel Polonovski, Lille, France
🇵🇱Wojewodzki Szpital Specjalistyczny im. M. Kopernika, Klinika Hematologii Instytutu Medycyny Wewnetrznej Uniwersytetu Medycznego w Lodzi, Lodz, Poland
🇩🇪Medizinische Poliklinik der Universität Hämatologie/Onkologie, Würzburg, Germany
Combination Chemotherapy With or Without Interferon Alfa in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma
- Conditions
- First Posted Date
- 2004-07-16
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- Scotland and Newcastle Lymphoma Group
- Target Recruit Count
- 200
- Registration Number
- NCT00003639
- Locations
- 🇬🇧
Royal Victoria Infirmary, Newcastle-upon-Tyne, England, United Kingdom
Combination Chemotherapy in Treating Patients With Advanced Hodgkin's Disease
- Conditions
- First Posted Date
- 2004-03-12
- Last Posted Date
- 2013-12-04
- Lead Sponsor
- Medical Research Council
- Target Recruit Count
- 800
- Registration Number
- NCT00003421
- Locations
- 🇬🇧
Weston Park Hospital, Sheffield, England, United Kingdom
🇬🇧St. James's Hospital, Leeds, England, United Kingdom
Chlorambucil Compared With No Further Therapy Following Anti-Helicobacter Therapy in Treating Patients With Low-Grade Lymphoma of the Stomach
- Conditions
- First Posted Date
- 2004-03-12
- Last Posted Date
- 2013-09-20
- Lead Sponsor
- Lymphoma Trials Office
- Target Recruit Count
- 200
- Registration Number
- NCT00003617
- Locations
- 🇬🇧
Clatterbridge Centre for Oncology NHS Trust, Merseyside, England, United Kingdom
🇬🇧Leeds Teaching Hospital Trust, Leeds, England, United Kingdom
🇬🇧Essex County Hospital, Colchester, England, United Kingdom
Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III or Stage IV Non-Hodgkin's Lymphoma
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-20
- Lead Sponsor
- Lymphoma Trials Office
- Target Recruit Count
- 500
- Registration Number
- NCT00006250
- Locations
- 🇬🇧
St. Thomas' Hospital, London, England, United Kingdom
🇬🇧Birmingham Heartlands Hospital, Birmingham, England, United Kingdom
🇬🇧Craigavon Area Hospital, Craigavon, Northern Ireland, United Kingdom
Chemotherapy in Treating Patients With Newly Diagnosed Chronic Lymphocytic Leukemia
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-12-18
- Lead Sponsor
- Leukemia Research Fund
- Registration Number
- NCT00004218
- Locations
- 🇮🇹
Ospedali Riuniti di Bergamo, Bergamo, Italy
🇮🇪St. James' Hospital, Dublin, Ireland
🇬🇧North Hampshire Hospital, Basingstoke, England, United Kingdom
Chlorambucil Compared With Radiation Therapy in Treating Patients With Previously Untreated Stage III or Stage IV Follicular Lymphoma
- Conditions
- First Posted Date
- 2003-01-27
- Last Posted Date
- 2013-09-17
- Lead Sponsor
- Commissie Voor Klinisch Toegepast Onderzoek
- Registration Number
- NCT00028691
- Locations
- 🇧🇪
Algemeen Ziekenhuis Middelheim, Antwerp, Belgium
🇳🇱Radiotherapeutisch Instituut Limburg-Maastricht, Maastricht, Netherlands
🇳🇱Daniel Den Hoed Cancer Center at Erasmus University Medical Center, Rotterdam, Netherlands
Drug Development Updates
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