奎奴普丁 (Synercid)

概览

Quinupristin is an antibiotic agent used in the treatment of serious vancomycin-resistant Enterococcus faecium bacteremia as well as complicated skin and skin structure infections.

作用机制

Quinupristin inhibits the late phase of protein synthesis in the bacterial ribosome. Dalfopristin binds to the 23S portion of the 50S ribosomal subunit, and changes the conformation it, enhancing the binding of quinupristin by a factor of about 100. In addition, it inhibits peptidyl transferase. Quinupristin binds to a nearby site on the 50S ribosomal subunit and prevents elongation of the polypeptide as well as causing incomplete chains to be released.

适应症

For the treatment of bacterial infections (usually in combination with dalfopristin).

• Bacterial Infections
• Methicillin Resistant Staphylococcus Aureus Infection (MRSA)
• Complicated Skin and subcutaneous tissue bacterial infection