Dimenhydrinate

Generic Name: Dimenhydrinate

Brand Names: Dramamine, Driminate, Gravol

Drug Type: Small Molecule

Chemical Formula: C_₂₄H_₂₈ClN_₅O_₃

CAS Number: 523-87-5

Unique Ingredient Identifier: JB937PER5C

Background: Dimehydrinate was first described in the literature in 1949, and patented in 1950. Early research into dimenhydrinate focused on its role as an antihistamine for urticaria; the treatment of motion sickness was an accidental discovery.

Dimenhydrinate, also known as B-dimethylaminoethyl benzohydrol ether 8-chlorotheophyllinate, is indicated to prevent nausea, vomiting, and dizziness caused by motion sickness. Dimenhydrinate is a combination of Diphenhydramine and 8-chlorotheophylline in a salt form, with 53%-55.5% dried diphenhydramine, and 44%-47% died 8-chlorotheophylline.

The antiemetic properties of dimenhydrinate are primarily thought to be produced by diphenhydramine's antagonism of H1 histamine receptors in the vestibular system while the excitatory effects are thought to be produced by 8-chlorotheophylline's adenosine receptor blockade.

When used in large doses, dimenhydrinate has been shown to cause a "high" characterized by hallucinations, excitement, incoordination, and disorientation.

Dimenhydrinate was granted FDA approval on 31 May 1972.

Indication: Dimenhydrinate is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.

Associated Conditions: Dizziness, Labyrinthine disorder, Menière's Disease, Morning Sickness, Motion Sickness, Nausea, Nausea and vomiting, Post Operative Nausea and Vomiting (PONV), Radiation-Induced Nausea and Vomiting, Vertigo, Vomiting

Clinical Trials

The Effect of Dimenhydrinate on Postoperative Nausea and Vomiting After Abdominal Hysterectomy: Randomized-controlled Trial

Not Applicable

Not yet recruiting

Conditions: Healthy Women
Gynecologic Neoplasm

Interventions: Drug: Dimenhydrinate

First Posted Date: 2024-05-01

Last Posted Date: 2024-05-01

Lead Sponsor: Preeyaporn Jirakittidul

Target Recruit Count: 160

Registration Number: NCT06395064

Dimenydrinate vs Ondansetron for PONV (DONV)

Not Applicable

Completed

Conditions: PONV in Laparoscopic Cholocystectomies

Interventions: Drug: Dimenhydrinate Tablets
Drug: Ondansetron iv

First Posted Date: 2022-10-21

Last Posted Date: 2022-12-08

Lead Sponsor: University of Thessaly

Target Recruit Count: 190

Registration Number: NCT05590936

Locations: 🇬🇷
University Hospital of Larisa, Department of Anesthesiology, Larissa, Thessaly, Greece

Recommendations of Enhanced Recovery Interventions for Patient's Clinical Team and Collection of Associated Data

Phase 3

Recruiting

Conditions: Perioperative Optimization

Interventions: Drug: Neuraxial Analgesia
Drug: Perphenazine
Drug: Ondansetron 4 MG
Drug: Aprepitant
Drug: Dimenhydrinate
Drug: Dexamethasone

First Posted Date: 2020-10-28

Last Posted Date: 2024-10-08

Lead Sponsor: Jennifer Holder-Murray

Target Recruit Count: 2500

Registration Number: NCT04606264

Locations: 🇺🇸
UPMC Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States
🇺🇸
UPMC Presbyterian, Pittsburgh, Pennsylvania, United States
🇺🇸
UPMC Passavant, Pittsburgh, Pennsylvania, United States

Comparison of Efficacy Dimenhydrinate and Metoclopramide in the Treatment of Nausea Due to Vertigo

Phase 4

Completed

Conditions: Vomiting
Nausea
Vertigo

Interventions: Drug: Dimenhydrinate
Drug: Metoclopramide

First Posted Date: 2014-10-01

Last Posted Date: 2014-10-01

Lead Sponsor: Pamukkale University

Target Recruit Count: 200

Registration Number: NCT02253524

Non Inferiority of Meclin® (Meclizine Chlorhydrate) Versus Dramin® (Dimenhydrinate) in Control of Acute Vertigo Symptoms From Peripheral Origin

Phase 3

Completed

Conditions: Vertigo, Peripheral

Interventions: Drug: Meclizine
Drug: Dimenhydrinate

First Posted Date: 2014-04-14

Last Posted Date: 2023-02-08

Lead Sponsor: Apsen Farmaceutica S.A.

Target Recruit Count: 292

Registration Number: NCT02112578

Locations: 🇧🇷
Clinica de Alergia MarttiAntila, Sorocaba, São Paulo, Brazil
🇧🇷
ISPEM, São José dos Campos, São Paulo, Brazil
🇧🇷
Clinilive, Maringá, Paraná, Brazil

and more 4 locations