TTRNA-xALT
- Generic Name
- TTRNA-xALT
Adoptive T Cell Therapy, DC Vaccines, and Hematopoietic Stem Cells Combined With Immune checkPOINT Blockade in Patients With Medulloblastoma
- Conditions
- Recurrent Group 3 MedulloblastomaRecurrent Group 4 (Non-SHH/Non-WNT) Medulloblastoma
- Interventions
- Biological: TTRNA-DC vaccines with GM-CSFDrug: Td vaccineBiological: autologous HSCs
- First Posted Date
- 2024-07-23
- Last Posted Date
- 2025-03-13
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 12
- Registration Number
- NCT06514898
- Locations
- 🇺🇸
University of Florida Health, Gainesville, Florida, United States
ADAGiO: Adoptive Cellular Therapy for the TreAtment of Recurrent OliGodendrogliOma (OG) Adult Patients
- Conditions
- Recurrent OligodendrogliomaProgressive Oligodendroglioma
- Interventions
- Biological: TTRNA-DC vaccines with GM-CSFBiological: Autologous Hematopoietic Stem cells (HSCs)Drug: Td vaccine
- First Posted Date
- 2024-02-12
- Last Posted Date
- 2025-03-04
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 12
- Registration Number
- NCT06254326
- Locations
- 🇺🇸
University of Florida Health Shands Hospital, Gainesville, Florida, United States
Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)
- Conditions
- Diffuse Intrinsic Pontine Glioma (DIPG)Brain Stem Glioma
- Interventions
- Biological: TTRNA-DC vaccines with GM-CSFDrug: Dose-Intensified TMZDrug: Td vaccineBiological: Autologous Hematopoietic Stem Cells (HSC)
- First Posted Date
- 2018-01-11
- Last Posted Date
- 2025-03-25
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 11
- Registration Number
- NCT03396575
- Locations
- 🇺🇸
UF Health Shands Children's Hospital, Gainesville, Florida, United States
Adoptive Cellular Therapy in Pediatric Patients With High-grade Gliomas
- Conditions
- High Grade GliomaMalignant Glioma
- Interventions
- Biological: TTRNA-DC vaccines with GM-CSFDrug: Dose-intensified TMZBiological: Autologous Hematopoietic Stem cells (HSCs)Drug: Td vaccine
- First Posted Date
- 2017-11-07
- Last Posted Date
- 2025-03-27
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 18
- Registration Number
- NCT03334305
- Locations
- 🇺🇸
Children's of Alabama at UAB, Birmingham, Alabama, United States
🇺🇸Children's National Hospital, Washington, District of Columbia, United States
🇺🇸UF Health Shands Children's Hospital, Gainesville, Florida, United States
Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor
- Conditions
- MedulloblastomaNeuroectodermal Tumor
- Interventions
- Biological: TTRNA-DCs
- First Posted Date
- 2011-03-30
- Last Posted Date
- 2025-04-27
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 26
- Registration Number
- NCT01326104
- Locations
- 🇺🇸
Children's Hospital Los Angeles, Los Angeles, California, United States
🇺🇸University of Florida, Gainesville, Florida, United States
🇺🇸Children's National Medical Center, Washington, District of Columbia, United States
Drug Development Updates
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