奥昔康唑 (Oxistat)

概览

Oxiconazole is a topical antifungal used to treat a variety of dermatophyte infections.

作用机制

Oxiconazole inhibits ergosterol biosynthesis, which is required for cytoplasmic membrane integrity of fungi. It acts to destabilize the fungal cyctochrome P450 51 enzyme (also known as Lanosterol 14-alpha demethylase). This is vital in the cell membrance structure of the fungus. Its inhibition leads to cell lysis. Oxiconazole has also been shown in inhibit DNA synthesis and suppress intracellular concentrations of ATP. Like other imidazole antifungals, Oxiconazole can increase membrane permeability to zinc, augmenting its cytotoxicity.

适应症

For treatment of dermal fungal infection.

• Fungal skin infection
• Pityriasis versicolor
• Tinea Corporis
• Tinea Cruris
• Tinea Pedis