MedPath

Zetomipzomib

Generic Name
Zetomipzomib
Drug Type
Small Molecule
Chemical Formula
C30H42N4O8
CAS Number
1629677-75-3
Unique Ingredient Identifier
O4BT6C02M2
Background

Zetomipzomib is under investigation in clinical trial NCT04033926 (A Phase 2 Study of KZR-616 to Evaluate Safety and Efficacy in Patients With Active Polymyositis or Dermatomyositis).

A Study of Zetomipzomib (KZR-616) in Patients with Active Lupus Nephritis (PALIZADE)

Phase 2
Terminated
Conditions
Lupus Nephritis
Interventions
Drug: placebo
First Posted Date
2023-03-23
Last Posted Date
2024-11-19
Lead Sponsor
Kezar Life Sciences, Inc.
Target Recruit Count
84
Registration Number
NCT05781750
Locations
🇺🇸

Nephrology Consultants, LLC, Huntsville, Alabama, United States

🇺🇸

Southwest Kidney Institute, Surprise, Arizona, United States

🇺🇸

Valerius Medical Group and Research Center of Greater Long Beach, Inc., Los Alamitos, California, United States

and more 179 locations

A Study of Zetomipzomib (KZR-616) in Patients With Autoimmune Hepatitis (PORTOLA)

Phase 2
Active, not recruiting
Conditions
Autoimmune Hepatitis
Interventions
First Posted Date
2022-10-06
Last Posted Date
2024-08-19
Lead Sponsor
Kezar Life Sciences, Inc.
Target Recruit Count
24
Registration Number
NCT05569759
Locations
🇺🇸

Northwell Health Center for Liver Disease and Transplantation, Manhasset, New York, United States

🇺🇸

University of Pennsylvania, Philadelphia, Pennsylvania, United States

🇺🇸

Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States

and more 21 locations

Open-label Extension to the Phase 2 Crossover Study (PRESIDIO) Evaluating KZR-616 in Patients With PM and DM.

Phase 2
Completed
Conditions
Polymyositis
Dermatomyositis
Interventions
First Posted Date
2020-11-16
Last Posted Date
2024-06-05
Lead Sponsor
Kezar Life Sciences, Inc.
Target Recruit Count
18
Registration Number
NCT04628936
Locations
🇨🇿

KZR Research Site, Prague, Czechia

A Phase 2 Study to Evaluate the Safety and Efficacy of KZR-616 in Patients With AIHA and ITP

Phase 2
Withdrawn
Conditions
Immune Thrombocytopenia
Autoimmune Hemolytic Anemia
Interventions
First Posted Date
2019-07-31
Last Posted Date
2020-08-07
Lead Sponsor
Kezar Life Sciences, Inc.
Registration Number
NCT04039477
Locations
🇺🇸

KZR-616 Research Site, Rochester, Minnesota, United States

🇷🇺

KZR Research Site, Saint Petersburg, Russian Federation

A Phase 2 Study of KZR-616 to Evaluate Safety and Efficacy in Patients With Active Polymyositis or Dermatomyositis

Phase 2
Completed
Conditions
Polymyositis
Dermatomyositis
Interventions
Drug: Placebo
First Posted Date
2019-07-26
Last Posted Date
2024-01-03
Lead Sponsor
Kezar Life Sciences, Inc.
Target Recruit Count
25
Registration Number
NCT04033926
Locations
🇩🇪

KZR Research Site, Göttingen, Germany

A Study of KZR-616 in Patients With SLE With and Without Lupus Nephritis

Phase 1
Completed
Conditions
Systemic Lupus Erythematosus
Lupus Nephritis
Interventions
First Posted Date
2018-01-08
Last Posted Date
2024-03-08
Lead Sponsor
Kezar Life Sciences, Inc.
Target Recruit Count
69
Registration Number
NCT03393013
Locations
🇺🇸

Hope Clinical Trials, Inc., Miami, Florida, United States

🇦🇺

Monash Health, Clayton, Victoria, Australia

🇦🇺

The Royal Melbourne Hospital, Parkville, Victoria, Australia

and more 33 locations
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