Tropisetron

Generic Name
Tropisetron
Brand Names
-
Drug Type
Small Molecule
Chemical Formula
C17H20N2O2
CAS Number
89565-68-4
Unique Ingredient Identifier
6I819NIK1W
Background

Tropisetron is an indole derivative with antiemetic activity. As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting.
...

Indication

For the prevention of nausea and vomiting induced by cytotoxic therapy and postoperative.

Associated Conditions
Chemotherapy-Induced Nausea and Vomiting
Associated Therapies
-
Clinical Trials
Related News

Triple Antiemetic Regimen for Chemoradiotherapy in Cervical Cancer or Nasopharyngeal Cancer

First Posted Date
2022-10-03
Last Posted Date
2024-02-06
Lead Sponsor
Shantou University Medical College
Target Recruit Count
116
Registration Number
NCT05564286
Locations
🇨🇳

Cancer Hospital of Shantou University Medical College, Shantou, Guangdong, China

Efficacy of Three Antiemetics in Preventing Nausea and Vomiting

First Posted Date
2022-09-09
Last Posted Date
2024-04-02
Lead Sponsor
The Second Affiliated Hospital of Chongqing Medical University
Target Recruit Count
200
Registration Number
NCT05533281
Locations
🇨🇳

The Second Affiliated Hospital, Chongqing Medical University, Chongqing, Chongqing, China

A Pilot Trial Evaluating the Effect of Tropisetron on Postoperative Cognitive Dysfunction After Cardiac Surgery

First Posted Date
2019-12-11
Last Posted Date
2022-01-05
Lead Sponsor
Beijing Chao Yang Hospital
Target Recruit Count
72
Registration Number
NCT04195204
Locations
🇨🇳

Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

The Efficacy and Safety of Tropisetron in Preventing Emergence Delirium

First Posted Date
2019-07-22
Last Posted Date
2020-03-11
Lead Sponsor
Beijing Chao Yang Hospital
Target Recruit Count
1508
Registration Number
NCT04027751
Locations
🇨🇳

Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

Not Applicable
Completed
Conditions
Postoperative Nausea and Vomiting
Interventions
Procedure: Automated recommendation at the start of the case
Procedure: Automated notification at the start of surgery
Procedure: Automated notification at the end of surgery
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Procedure: Elective surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Isoflurane
Drug: Desflurane
Drug: Scopolamine
Drug: Droperidol
Drug: Haloperidol
Drug: Dexamethasone
Drug: Promethazine
Drug: Meclizine
Drug: Aprepitant
Drug: Metoclopramide
Drug: Fentanyl
Drug: Sufentanil
Drug: Alfentanil
Drug: Remifentanil
Drug: Morphine
Drug: Meperidine
Drug: Hydromorphone
Drug: Methadone
Drug: Oxycodone
Drug: Oxymorphone
Drug: Hydrocodone
Drug: Ketamine
Drug: Ondansetron
Drug: Granisetron
Drug: Dolasetron mesylate
Drug: Palonosetron
Drug: Tropisetron
Drug: Ramosetron
First Posted Date
2015-12-09
Last Posted Date
2019-03-07
Lead Sponsor
Vanderbilt University
Target Recruit Count
27034
Registration Number
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Locations
🇺🇸

Vanderbilt University Medical Center, Nashville, Tennessee, United States

A Study Evaluating the Efficacy and Safety of Aprepitant in Autologous Hematopoietic Stem Cell Transplantation

First Posted Date
2015-10-15
Last Posted Date
2016-12-30
Lead Sponsor
Jun Zhu
Target Recruit Count
130
Registration Number
NCT02576327

Transcutaneous Electrical Acupoint Stimulation of P6 to Prevent Postoperation Nausea and Vomiting

First Posted Date
2014-03-26
Last Posted Date
2015-10-12
Lead Sponsor
Huashan Hospital
Target Recruit Count
157
Registration Number
NCT02096835
Locations
🇨🇳

Department of Anesthesiology, North Institute of Huashan Hospital,Fudan University, Shanghai, Shanghai, China

Acupoint Electric Stimulation Combined With Tropisetron in Preventing and Treating Nausea and Vomiting After TACE

First Posted Date
2013-07-10
Last Posted Date
2013-07-10
Lead Sponsor
Fudan University
Target Recruit Count
74
Registration Number
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Locations
🇨🇳

Shanghai Cancer Center, Shanghai, Shanghai, China

The Central Analgesic Effects of Paracetamol on Serotonergic Pathways

Not Applicable
Completed
Conditions
Analgesia
Interventions
Drug: Paracetamol
Drug: Placebo
Drug: Tropisetron
First Posted Date
2009-09-02
Last Posted Date
2013-01-29
Lead Sponsor
University Hospital, Basel, Switzerland
Target Recruit Count
16
Registration Number
NCT00970450
Locations
🇨🇭

University Hospital of Basel, Basel, Switzerland

Clinical Confirmation of a Pharmacodynamic Interaction Between Tropisetron and Paracetamol

Phase 4
Completed
Conditions
Pain
First Posted Date
2007-06-15
Last Posted Date
2010-03-29
Lead Sponsor
University Hospital, Clermont-Ferrand
Target Recruit Count
40
Registration Number
NCT00487110
Locations
🇫🇷

CHU, Clermont-Ferrand, France

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