Testosterone

Generic Name: Testosterone

Brand Names: Androderm, Androgel, Axiron, Fortesta, Natesto, Striant, Testim, Testopel, Vogelxo

Drug Type: Small Molecule

Chemical Formula: C_₁₉H_₂₈O_₂

CAS Number: 58-22-0

Unique Ingredient Identifier: 3XMK78S47O

Background: Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism. Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual characteristics.

Testosterone was isolated from samples and also synthesized in 1935.

Indication: Testosterone is indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.

Associated Conditions: Hypergonadotropic Hypogonadism, Hypogonadotrophic Hypogonadism, Idiopathic Hypogonadotropic Hypogonadism, Puberty, Delayed, Inoperable, metastatic Breast cancer

Associated Therapies: -

Clinical Trials

Impact of Estradiol Addback

Phase 1

Completed

Conditions: Normal Healthy Volunteers

Interventions: Drug: Degarelix
Drug: Testosterone
Drug: Anastrozole
Drug: Estrogen patch

First Posted Date: 2013-05-27

Last Posted Date: 2019-06-07

Lead Sponsor: Mayo Clinic

Target Recruit Count: 43

Registration Number: NCT01862835

Locations: 🇺🇸
Mayo Clinic in Rochester, Rochester, Minnesota, United States

Constitutional Delay of Growth and Puberty: Towards Evidence-based Treatment

Phase 2

Completed

Conditions: Constitutional Delay of Growth and Puberty

Interventions: Drug: Testosterone
Drug: Letrozole

First Posted Date: 2013-02-22

Last Posted Date: 2018-02-06

Lead Sponsor: Helsinki University Central Hospital

Target Recruit Count: 35

Registration Number: NCT01797718

Locations: 🇫🇮
Kotka Central Hospital, Kotka, Finland
🇫🇮
Kuopio University Central Hospital, Kuopio, Finland
🇫🇮
Helsinki University Central Hospital, Helsinki, Finland

and more 1 locations

Testosterone Antidepressant Augmentation in Women

Not Applicable

Completed

Conditions: Depression

Interventions: Drug: Placebo
Drug: Testosterone

First Posted Date: 2013-02-05

Last Posted Date: 2018-06-06

Lead Sponsor: Massachusetts General Hospital

Target Recruit Count: 101

Registration Number: NCT01783574

Locations: 🇺🇸
Butler Hospital, Providence, Rhode Island, United States
🇺🇸
Massachusetts General Hospital, Boston, Massachusetts, United States

Lybridos in Pre- and Postmenopausal Women With Hypoactive Sexual Desire Disorder Due to Maladaptive Activation of Sexual Inhibitory Systems

Phase 2

Completed

Conditions: Hypoactive Sexual Desire Disorder

Interventions: Drug: Placebo
Drug: Testosterone
Drug: Buspirone hydrochloride

First Posted Date: 2012-12-06

Last Posted Date: 2014-03-31

Lead Sponsor: Emotional Brain NY Inc.

Target Recruit Count: 207

Registration Number: NCT01743235

Locations: 🇺🇸
Compass Research, Orlando, Florida, United States
🇺🇸
Maryland Prime Care Physicians, Stevensville, Maryland, United States
🇺🇸
Center for Sexual Medicine at Sheppard Pratt, Townson, Maryland, United States

and more 8 locations

A Study of Effect of Deodorant and Axillary Hair on Testosterone Absorption in Healthy Participants

Phase 1

Completed

Conditions: Healthy Participants

Interventions: Drug: Testosterone
Other: Deodorant and Antiperspirant Combination Spray
Other: Deodorant and Antiperspirant Combination Stick
Other: Deodorant Spray

First Posted Date: 2012-11-12

Last Posted Date: 2014-10-16

Lead Sponsor: Eli Lilly and Company

Target Recruit Count: 30

Registration Number: NCT01725451

Locations: 🇺🇸
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., Evansville, Indiana, United States

Breast Cancer, Aromatase Inhibitor Therapy, and Sexual Functioning: The Effects of Vaginal Testosterone Therapy

Early Phase 1

Completed

Conditions: Dyspareunia
Vaginal Dryness
Sexual Health Quality of Life
Breast Cancer

Interventions: Drug: Testosterone

First Posted Date: 2012-10-02

Last Posted Date: 2014-01-24

Lead Sponsor: Creighton University

Target Recruit Count: 12

Registration Number: NCT01697345

Locations: 🇺🇸
Nebraska Cancer Specialists/Midwest Cancer Center - Legacy, Omaha, Nebraska, United States

Testosterone and Weight Loss

Phase 2

Completed

Conditions: Obesity in Men

Interventions: Drug: placebo
Drug: Testosterone

First Posted Date: 2012-06-12

Last Posted Date: 2016-06-06

Lead Sponsor: Austin Health

Target Recruit Count: 100

Registration Number: NCT01616732

Locations: 🇦🇺
Austin Health, Heidelberg, Victoria, Australia

Testosterone Administration and ACL Reconstruction in Men

Phase 3

Completed

Conditions: Trauma
Muscle Atrophy
ACL Reconstruction
Osteoarthritis

Interventions: Drug: Placebo
Drug: Testosterone

First Posted Date: 2012-05-10

Last Posted Date: 2022-03-02

Lead Sponsor: University of Southern California

Target Recruit Count: 14

Registration Number: NCT01595581

Locations: 🇺🇸
University of Southern California, Los Angeles, California, United States

Study of Psychological and Motor Effects of Testosterone in Adolescents With XXY/Klinefelter Syndrome

Not Applicable

Completed

Conditions: Klinefelter Syndrome
XXY Syndrome

Interventions: Drug: Testosterone gel 1%
Drug: Placebo gel

First Posted Date: 2012-04-26

Last Posted Date: 2021-08-10

Lead Sponsor: University of Colorado, Denver

Target Recruit Count: 48

Registration Number: NCT01585831

Locations: 🇺🇸
Childrens Hospital Colorado, Aurora, Colorado, United States

Testosterone in Treating Postmenopausal Patients With Arthralgia Caused by Adjuvant Aromatase Inhibitor Treatment

Phase 3

Completed

Conditions: Arthralgia
Breast Cancer
Sexual Dysfunction
Hot Flashes
Musculoskeletal Complications

Interventions: Drug: testosterone
Other: placebo

First Posted Date: 2012-04-09

Last Posted Date: 2022-11-21

Lead Sponsor: Alliance for Clinical Trials in Oncology

Target Recruit Count: 227

Registration Number: NCT01573442

Locations: 🇺🇸
Rocky Mountain Cancer Centers - Pueblo, Pueblo, Colorado, United States
🇺🇸
Marshfield Clinic - Weston Center, Weston, Wisconsin, United States
🇺🇸
Cedars Sinai Medical Center, Los Angeles, California, United States

and more 525 locations

Drug Development Updates

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