Overview
Dequalinium is an antibacterial agent with multi-targeted actions. It also possesses antifungal, antiparasitic, antiviral, anticancer, and neuroprotective properties. It is a quaternary ammonium compound, as it consists of an amphipathic cation with two aminoquinaldinium rings at both ends of a long hydrophobic hydrocarbon chain. Due to its flexible structure, dequalinium was investigated to build drug and gene delivery systems. First used as an antiseptic and disinfectant in the 1950s, dequalinium is still found in various OTC products to treat conditions of oral infections and inflammation. It is also used in vaginal tablets to treat bacterial vaginosis.
Indication
Dequalinium is used in several OTC products to treat mouth infections and inflammation, such as tonsillitis, pharyngitis, and gingivitis. As vaginal tablets, dequalinium is indicated for the treatment of bacterial vaginosis in adult women under 55 years of age.
Associated Conditions
- Bacterial Vaginosis (BV)
- Gingivitis
- Inflammation of Mouth
- Oral Candidiasis
- Oral Malodor (Halitosis)
- Oral bacterial infection
- Pharyngitis
- Stomatitis
- Tonsillitis
- Oral infections
- Throat infections
- Throat inflammation
- Tongue inflammation
- Ulceration of the mouth
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2023/03/29 | Phase 4 | Terminated | |||
2010/05/18 | Phase 3 | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| ALSOOTH LOZENGES | N/A | N/A | N/A | 6/15/2001 | |
| NOFROZIC MINT FLAVOUR LOZ 0.25MG | N/A | fortune pharmacal co ltd | N/A | N/A | 1/16/2002 |
| DECATYLEN LOZ | N/A | N/A | N/A | 3/19/1990 | |
| THROAT-AID LOZENGES | N/A | N/A | N/A | 3/28/2001 | |
| DEQUADIN LOZ COLOURED ORANGE 0.25MG | N/A | N/A | N/A | 9/11/1985 | |
| DEQUADIN MINT LOZENGE 0.25MG | N/A | N/A | N/A | 9/28/2009 | |
| DEQUADIN LOZ LEMON FLAVOUR 0.25MG | N/A | N/A | N/A | 9/11/1985 | |
| DEQUALINIUM CHLORIDE LOZ 0.25MG | N/A | N/A | N/A | 2/22/1980 |
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| DEQUADIN MINT LOZ 0.25MG | glaxo canada inc | 00110566 | Lozenge - Oral | .25 MG / LOZ | 12/31/1985 |
| DEQUADIN ORAL SPRAY | 02522616 | Solution - Buccal | 0.5 % / W/V | 9/28/2022 | |
| DEQUADIN LOZENGES .25MG | glaxo canada inc | 00110566 | Lozenge - Oral | .25 MG / LOZ | 12/31/1958 |
| DEQUADIN | 02100207 | Lozenge - Oral | 0.25 MG | 12/30/1996 | |
| DEQUADIN ORAL PAINT .5% | glaxo canada inc | 00110574 | Paint - Oral | 0.5 % | 12/31/1958 |
| VABLYS | 02518252 | Vaginal Tablet - Vaginal | 10 MG | 5/17/2022 | |
| DEQUADIN ORAL PAINT | 02091453 | Solution - Buccal | 0.5 % / W/V | 12/31/1995 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| No CIMA AEMPS (Spain) approvals found for this drug. | |||||
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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