阿屈替诺 (Panretin)

概览

Alitretinoin is a vitamin A derivative used to treat Kaposi's sarcoma and used off label to treat chronic hand eczema and psoriasis.

作用机制

Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells.

适应症

外用可用于局部治疗艾滋病相关的卡波西肉瘤且未接受全身治疗的皮肤损伤。口服可用于局部外用强效糖皮质激素无效的慢性手部湿疹患者。

• Chronic Eczema of the hand
• Cutaneous lesions
• Refractory Eczema of the hand
• Severe Eczema of the hand