Overview
An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute).
Background
An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute).
Indication
外用可用于局部治疗艾滋病相关的卡波西肉瘤且未接受全身治疗的皮肤损伤。口服可用于局部外用强效糖皮质激素无效的慢性手部湿疹患者。
Associated Conditions
- Chronic Eczema of the hand
- Cutaneous lesions
- Refractory Eczema of the hand
- Severe Eczema of the hand
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2017/01/20 | Phase 3 | UNKNOWN | |||
2017/01/20 | Phase 3 | UNKNOWN | |||
2013/07/03 | N/A | Completed | University Hospital, Gentofte, Copenhagen | ||
2012/02/24 | Phase 2 | UNKNOWN | |||
2011/08/02 | Phase 2 | Terminated | University Hospital Muenster | ||
2010/12/17 | Phase 1 | Completed | University Hospital, Gentofte, Copenhagen | ||
2010/11/22 | Phase 2 | Completed | Stiefel, a GSK Company | ||
2010/11/01 | Phase 4 | Terminated | |||
2009/01/06 | Phase 3 | Completed | Stiefel, a GSK Company | ||
2007/08/23 | Phase 3 | Completed |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| Concordia Pharmaceuticals Inc. | 59212-601 | TOPICAL | 60 mg in 60 g | 9/10/2019 | |
| Sincerus Florida, LLC | 72934-2054 | TOPICAL | 0.05 g in 100 g | 6/4/2020 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| No TGA approvals found for this drug. | |||||