Amoxicillin

Generic Name: Amoxicillin

Brand Names: Amoxil, Augmentin, Clavulin, Moxatag, Omeclamox, Prevpac, Talicia, Voquezna 14 Day Dualpak 20;500, Voquezna 14 Day Triplepak 20;500;500

Drug Type: Small Molecule

Chemical Formula: C_₁₆H_₁₉N_₃O_₅S

CAS Number: 26787-78-0

Unique Ingredient Identifier: 9EM05410Q9

Background: Amoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972. Amoxicillin has similar activity to penicillin and ampicillin, but leads to higher serum concentrations than ampicillin.

Amoxicillin was granted FDA approval on 18 January 1974.

Indication: Amoxicillin alone is indicated to treat susceptible bacterial infections of the ear, nose, throat, genitourinary tract, skin, skin structure, and lower respiratory tract. Amoxicillin is given with calvulanic acid to treat acute bacterial sinusitis, community acquired pneumonia, lower respiratory tract infections, acute bacterial otitis media, skin and skin s...

Associated Conditions: Acute Bacterial Sinusitis (ABS), Acute Otitis Media (AOM), Bacterial Infections, Community Acquired Pneumonia (CAP), Duodenal ulcer caused by helicobacter pylori, Genitourinary tract infection, Helicobacter Pylori Infection, Lower Respiratory Tract Infection (LRTI), Peptic Ulcer With H. Pylori Infection, Sinusitis, Skin and Subcutaneous Tissue Bacterial Infections, Urinary Tract Infection, Acute, uncomplicated Gonorrhea, Ear, nose, and throat infections

Associated Therapies: -

Clinical Trials

Efficacy of Therapy Based on Fecal Molecular Antimicrobial Susceptibility Tests for Helicobacter Pylori Infection

Phase 4

Recruiting

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Rabeprazole
Drug: Colloidal Bismuth Pectin Granules
Drug: Amoxicillin
Drug: Clarithromycin
Drug: Furazolidone

First Posted Date: 2023-02-08

Last Posted Date: 2023-05-15

Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Target Recruit Count: 855

Registration Number: NCT05718609

Locations: 🇨🇳
Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, Zhejiang, China

The Effect of Probiotics on Gut Microbiotain After Helicobacter Pylori Eradication

Phase 4

Not yet recruiting

Conditions: Helicobacter Pylori Infection
Infections
Intestinal Bacteria Flora Disturbance

Interventions: Drug: Vonoprazan
Drug: Amoxicillin
Drug: probiotics

First Posted Date: 2022-12-20

Last Posted Date: 2023-02-08

Lead Sponsor: Nanjing First Hospital, Nanjing Medical University

Target Recruit Count: 100

Registration Number: NCT05658055

Locations: 🇨🇳
Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China

Optimization of Vonoprazan-based Dual Therapy for Helicobacter Pylori

Phase 4

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Vonoprazan
Drug: Amoxicillin

First Posted Date: 2022-12-14

Last Posted Date: 2024-11-19

Lead Sponsor: Nanjing First Hospital, Nanjing Medical University

Target Recruit Count: 900

Registration Number: NCT05649540

Locations: 🇨🇳
Changzhou Traditional Chinese Medicine Hospital, Changzhou, Jiangsu, China
🇨🇳
Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
🇨🇳
The Affiliated Zhangjiagang Hospital of Soochow University, Zhangjiagang, Jiangsu, China

and more 10 locations

Azithromycin for Severe Acute Malnutrition in CMAM, Nigeria

Phase 3

Terminated

Conditions: Severe Acute Malnutrition

Interventions: Drug: Amoxicillin
Drug: Azithromycin

First Posted Date: 2022-07-25

Last Posted Date: 2024-03-08

Lead Sponsor: University of California, San Francisco

Target Recruit Count: 307

Registration Number: NCT05473234

Locations: 🇳🇬
The Tamaika Project, Gombe, Gombe State, Nigeria

Efficacy and Safety of Dual Therapy for Helicobacter Pylori Eradication

Phase 4

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Vonoprazan
Drug: Amoxicillin

First Posted Date: 2022-07-22

Last Posted Date: 2024-06-13

Lead Sponsor: Nanjing First Hospital, Nanjing Medical University

Target Recruit Count: 914

Registration Number: NCT05469685

Locations: 🇨🇳
Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China
🇨🇳
Changshu No.1 People's Hospital, Suzhou, Jiangsu, China
🇨🇳
Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China

and more 7 locations

Geisinger Antibiotic Allergy Pilot Program: Assess and Address

Early Phase 1

Recruiting

Conditions: Penicillin Allergy

Interventions: Drug: Amoxicillin

First Posted Date: 2022-07-19

Last Posted Date: 2024-04-30

Lead Sponsor: Geisinger Clinic

Target Recruit Count: 100

Registration Number: NCT05464615

Locations: 🇺🇸
Geisinger Community Medical Center, Scranton, Pennsylvania, United States
🇺🇸
Geisinger Wyoming Valley, Wilkes-Barre, Pennsylvania, United States
🇺🇸
Geisinger Medical Center, Danville, Pennsylvania, United States

Surgical Access Combined With Systematically Administered Antibiotics in the Treatment of Peri-implantitis

Not Applicable

Completed

Conditions: Peri-Implantitis

Interventions: Procedure: Open flap debridement
Drug: Placebos
Drug: Metronidazole
Drug: Amoxicillin

First Posted Date: 2022-07-05

Last Posted Date: 2024-07-18

Lead Sponsor: University of Guarulhos

Target Recruit Count: 89

Registration Number: NCT05444218

Locations: 🇧🇷
University of Guarulhos, Guarulhos, São Paulo, Brazil

Bismuth-containing Quadruple Therapy for Helicobacter Pylori First-line Treatment of Different Tetracycline Doses

Phase 4

Completed

Conditions: Helicobacter Pylori Infection

Interventions: Drug: Amoxicillin
Drug: Tetracycline tid
Drug: Tetracycline qid
Drug: Bismuth Potassium Citrate
Drug: Colloidal Bismuth Pectin
Drug: Esomeprazole 20mg

First Posted Date: 2022-06-24

Last Posted Date: 2024-03-27

Lead Sponsor: Shandong University

Target Recruit Count: 406

Registration Number: NCT05431075

Locations: 🇨🇳
Zhengzhou Central Hospital, Zhengzhou, Henan, China
🇨🇳
Qilu hosipital, Jinan, Shandong, China
🇨🇳
Taierzhuang District People's Hospital, Taierzhuang, Shandong, China

and more 3 locations