Unknown Manufacturer
αAβ–Gas6 is a chimeric fusion protein being investigated for Alzheimer's disease.
αAβ–Gas6 is a chimeric fusion protein being investigated for Alzheimer's disease.
TAM (TYRO3, AXL, and MERTK) receptors are receptor tyrosine kinases expressed ubiquitously, including microglia and astrocytes of the nervous system. They play a critical role in homeostatic processes such as phagocytosis of apoptotic cells and membranous organelles, and regulation of inflammatory responses and inflammation. αAβ-Gas6 targets TAM receptors by binding to growth arrest-specific 6 (Gas6), a ligand for TAM receptors. By activating the TAM receptor signalling pathway, αAβ-Gas6 promotes TAM receptor-dependent phagocytosis to selectively eliminate Aβ plaques without affecting NF-kB-mediated inflammatory responses or reactive gliosis.
One entry per invention. Patent families filed in the US, EP, WO and CN offices.
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Patent documents usually refer to a drug by its chemical name or development code rather than its generic name, and applications are only published about 18 months after filing — so a newer drug may not appear here yet.
