Dimethyl fumarate
- Generic Name
- Dimethyl fumarate
- Brand Names
- Tecfidera, Skilarence, Dimethyl fumarate Neuraxpharm, Dimethyl fumarate Mylan, Dimethyl fumarate Accord
- Drug Type
- Small Molecule
- Chemical Formula
- C6H8O4
- CAS Number
- 624-49-7
- Unique Ingredient Identifier
- FO2303MNI2
- Background
Dimethyl fumarate is an agent indicated for the treatment of relapsing forms of multiple sclerosis. The mechanism of action of dimethyl fumarate in multiple sclerosis is not well understood. It is thought to involve dimethyl fumarate degradation to its active metabolite monomethyl fumarate (MMF) then MMF up-regulates the Nuclear factor (erythroid-derived 2)-...
- Indication
Dimethyl fumarate is indicated for the treatment of relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
- Associated Conditions
- Clinically Isolated Syndrome (CIS), Relapsing Forms of MS, Relapsing Remitting Multiple Sclerosis (RRMS), Active Secondary Progressive Multiple Sclerosis (SPMS)
- Associated Therapies
- -
Study on Therapy With Dimethylfumarate (DMF) in Patients With Cutaneous T Cell Lymphoma (CTCL)
- First Posted Date
- 2015-09-10
- Last Posted Date
- 2023-03-31
- Lead Sponsor
- Universitätsmedizin Mannheim
- Target Recruit Count
- 25
- Registration Number
- NCT02546440
- Locations
- 🇩🇪
University Medical Center, Mannheim, Germany
Effect of BG00012 on Lymphocyte Subsets and Immunoglobulins in Subjects With Relapsing Remitting Multiple Sclerosis (RRMS).
- Conditions
- Interventions
- First Posted Date
- 2015-08-18
- Last Posted Date
- 2019-06-27
- Lead Sponsor
- Biogen
- Target Recruit Count
- 218
- Registration Number
- NCT02525874
- Locations
- 🇹🇷
Research Site, Umuttepe, Kocaeli, Turkey
Tecfidera Lymphocyte Chart Review
- Conditions
- First Posted Date
- 2015-08-10
- Last Posted Date
- 2016-08-26
- Lead Sponsor
- Biogen
- Target Recruit Count
- 483
- Registration Number
- NCT02519413
- Locations
- 🇺🇸
Research site, Homewood, Alabama, United States
🇺🇸Research Site, Milwaukee, Wisconsin, United States
Study to Explore the Onset of Efficacy on Magnetic Resonance Disease Activity of BG00012 (Dimethyl Fumarate) in Patients With Relapsing remitTing Multiple Sclerosis
- Conditions
- Interventions
- First Posted Date
- 2015-06-16
- Last Posted Date
- 2015-12-28
- Lead Sponsor
- Biogen
- Registration Number
- NCT02472938
Tecfidera and the Gut Microbiota
- Conditions
- Interventions
- First Posted Date
- 2015-06-15
- Last Posted Date
- 2021-09-05
- Lead Sponsor
- Biogen
- Target Recruit Count
- 36
- Registration Number
- NCT02471560
- Locations
- 🇳🇴
Research site, Stavanger, Norway
🇳🇴Research Site, Lillehammer, Norway
Investigation of the Effect of Dimethyl Fumarate on T Cells in Patients With Relapsing Remitting Multiple Sclerosis
- Conditions
- Interventions
- First Posted Date
- 2015-06-03
- Last Posted Date
- 2018-10-11
- Lead Sponsor
- University Hospital Muenster
- Target Recruit Count
- 67
- Registration Number
- NCT02461069
- Locations
- 🇩🇪
University Hospital Muenster, Department of Neurology, Muenster, Germany
🇩🇪Neurologische Univ.-Klinik, Heidelberg, Germany
🇩🇪Klinik und Poliklinik für Neurologie, Universitätsklinikum Mainz, Mainz, Germany
Dimethyl Fumarate for Obstructive Sleep Apnea
- Conditions
- Interventions
- First Posted Date
- 2015-05-08
- Last Posted Date
- 2017-05-31
- Lead Sponsor
- University of Michigan
- Target Recruit Count
- 65
- Registration Number
- NCT02438137
- Locations
- 🇺🇸
University of Michigan, Ann Arbor, Michigan, United States
BG00012 and Delay of Disability Progression in Secondary Progressive Multiple Sclerosis
- Conditions
- Interventions
- First Posted Date
- 2015-04-30
- Last Posted Date
- 2017-04-26
- Lead Sponsor
- Biogen
- Target Recruit Count
- 58
- Registration Number
- NCT02430532
- Locations
- 🇸🇰
Research Site, Banska Bystrica, Slovakia
Placebo-Controlled Study of the Efficacy and Safety of BG00012 in Pediatric Subjects With Relapsing-Remitting Multiple Sclerosis (RRMS)
- Conditions
- Interventions
- First Posted Date
- 2015-04-28
- Last Posted Date
- 2016-04-13
- Lead Sponsor
- Biogen
- Registration Number
- NCT02428218
Tecfidera Slow-Titration Study
- First Posted Date
- 2015-04-28
- Last Posted Date
- 2017-05-05
- Lead Sponsor
- Biogen
- Target Recruit Count
- 62
- Registration Number
- NCT02428231
- Locations
- 🇮🇹
Research Site, Montichiari, Italy
Drug Development Updates
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