Ropivacaine

Generic Name: Ropivacaine

Brand Names: Naropin

Drug Type: Small Molecule

Chemical Formula: C_₁₇H_₂₆N_₂O

CAS Number: 84057-95-4

Unique Ingredient Identifier: 7IO5LYA57N

Background: Ropivacaine is an aminoamide local anesthetic drug marketed by AstraZeneca under the trade name Naropin. It exists as a racemate of its S- and R-enantiomers, although the marketed form is supplied only as the purified S-enantiomer.

Indication: Ropivacaine is indicated in adult patients for the induction of regional or local anesthesia for surgery or acute pain management.

Associated Conditions: Acute Pain, Postoperative pain

Associated Therapies: Surgical anesthesia therapy

Clinical Trials

Postsurgical Analgesia After Hernia Repair

Phase 2

Not yet recruiting

Conditions: Hernia
Hernia, Abdominal

Interventions: Drug: AMT-143 hydrogel containing containing ropivacaine
Drug: Ropivacaine
Other: Placebo

First Posted Date: 2024-11-29

Last Posted Date: 2024-12-06

Lead Sponsor: AmacaThera Inc.

Target Recruit Count: 30

Registration Number: NCT06709612

Locations: 🇨🇦
McMaster University, Hamilton, Ontario, Canada

QLESP Block Versus Periarticular Infiltration for Postoperative Analgesia in Hip Surgery

Not Applicable

Recruiting

Conditions: Regional Anaesthesia

Interventions: Drug: ropivacaine

First Posted Date: 2024-11-14

Last Posted Date: 2024-11-20

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 80

Registration Number: NCT06688136

Locations: 🇨🇳
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

Dexmedetomidine Ropivacaine Versus Plain Ropivacaine in Bilateral Pectoralis Nerve (PECS) Block

Phase 4

Recruiting

Conditions: Analgesia

Interventions: Drug: dexmedetomidine
Drug: fentanyl
Drug: ropivacaine

First Posted Date: 2024-10-10

Last Posted Date: 2024-10-11

Lead Sponsor: Fayoum University

Target Recruit Count: 90

Registration Number: NCT06636578

Locations: 🇪🇬
Mohamed Hamed, Fayoum, Egypt
🇪🇬
Fayoum University Hospital, Fayoum, Egypt

Phase 2 Pharmacokinetics Study of TLC590 for Postsurgical Pain Management in Multiple Surgical Models

Phase 2

Recruiting

Conditions: Postsurgical Pain Management

Interventions: Drug: TLC590
Drug: Ropivacaine

First Posted Date: 2024-08-27

Last Posted Date: 2024-11-04

Lead Sponsor: Taiwan Liposome Company

Target Recruit Count: 120

Registration Number: NCT06574269

Locations: 🇺🇸
First Surgical Hospital, Bellaire, Texas, United States
🇺🇸
Memorial Hermann Village, Houston, Texas, United States

Analgesic Efficacy of an Opioid-free Postoperative Pain Management Strategy Versus a Conventional Opioid-based Strategy Following Video-assisted Thoracoscopic Lobectomy

Early Phase 1

Not yet recruiting

Conditions: Postoperative Pain

Interventions: Drug: Ropivacaine
Drug: Sufentanil

First Posted Date: 2024-08-26

Last Posted Date: 2024-08-26

Lead Sponsor: Affiliated Cancer Hospital & Institute of Guangzhou Medical University

Target Recruit Count: 140

Registration Number: NCT06570538

Bupivacaine Liposome Plus Bupivacaine or Ropivacaine for Pericapsular Nerve Group Block in Hip Arthroplasty (PENG)

Phase 4

Not yet recruiting

Conditions: Hip Fractures
Femoral Neck Fractures
Femur Head Necrosis

Interventions: Drug: Liposomal bupivacaine plus bupivacaine
Drug: Ropivacaine

First Posted Date: 2024-08-22

Last Posted Date: 2024-08-22

Lead Sponsor: Huazhong University of Science and Technology

Target Recruit Count: 60

Registration Number: NCT06565910

Locations: 🇨🇳
Department of Anesthesiology, Tongji Hospital, Tongji Medical College, HUST, Wuhan, Hubei, China

The Analgesic Efficacy of Pericapsular Nerve Group (PENG) Block in Patients Undergoing Primary Total Hip Arthoplasty:

Not Applicable

Recruiting

Conditions: Prospective
Randomized
Double-blind

Interventions: Drug: Ropivacaine
Other: Physiological saline

First Posted Date: 2024-08-16

Last Posted Date: 2024-08-16

Lead Sponsor: Diakonie-Klinikum Stuttgart

Target Recruit Count: 110

Registration Number: NCT06557044

Locations: 🇩🇪
Diakonie-Klinikum Stuttgart, Stuttgart, Baden-Württemberg, Germany

Effect of Ultrasound-guided Erector Spinae Plane Block on Postoperative Pain and Sleep Quality of Infants With Congenital Pulmonary Cystic Disease After Thoracoscopic Surgery

Not Applicable

Recruiting

Conditions: Bronchopulmonary Sequestration
Cystic Adenomatoid Malformation of Lung, Congenital
Bronchogenic Cyst

Interventions: Drug: Ropivacaine
Procedure: Incision infiltration of local anesthesia
Procedure: erector spinae plane block

First Posted Date: 2024-07-12

Last Posted Date: 2024-07-16

Lead Sponsor: Lei Xiaoming

Target Recruit Count: 40

Registration Number: NCT06498583

Locations: 🇨🇳
Second Affiliated Hospital of Xi 'an Jiaotong University, Xi'an, Shanxi, China

Dexamethasone With Ropivacaine for PENG Block in Total Hip Arthroplasty

Phase 4

Recruiting

Conditions: Hip Arthritis
Hip Osteoarthritis
Hip Pain Chronic

Interventions: Drug: Ropivacaine
Drug: Ropivacaine+Dexamethasone

First Posted Date: 2024-06-24

Last Posted Date: 2024-12-09

Lead Sponsor: Poznan University of Medical Sciences

Target Recruit Count: 60

Registration Number: NCT06470334

Locations: 🇵🇱
Poznan University of Medical Sciences, Poznan, Poznań, Poland

Dexamethasone for iPACK Block With ACB in Total Knee Arthroplasty

Phase 4

Not yet recruiting

Conditions: Knee Osteoarthritis
Knee Pain Chronic
Knee Arthritis

Interventions: Drug: Ropivacaine+Dexamethasone
Drug: Ropivacaine

First Posted Date: 2024-06-24

Last Posted Date: 2024-08-09

Lead Sponsor: Poznan University of Medical Sciences

Target Recruit Count: 60

Registration Number: NCT06470204

Locations: 🇵🇱
Poznan University of Medical Sciences, Poznan, Poznań, Poland

Drug Development Updates

Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.

Home Terms & Conditions Privacy Policy