Clobetasol propionate
- Generic Name
- Clobetasol propionate
- Brand Names
- Clobex, Clodan, Dermovate, Impeklo, Impoyz, Olux, Temovate, Tovet
- Drug Type
- Small Molecule
- Chemical Formula
- C25H32ClFO5
- CAS Number
- 25122-46-7
- Unique Ingredient Identifier
- 779619577M
- Background
Clobetasol propionate is a prednisolone derivative with higher specificity for glucocorticoid receptors than mineralocorticoid receptors. It has demonstrated superior activity compared to fluocinonide and was first described in the literature in 1974.
Clobetasol Propionate was granted FDA approval on 27 December 1985.
- Indication
Clobetasol propionate is indicated to treat moderate to severe plaque psoriasis as well as inflammatory and pruritic manifestations of corticosteroid responsive dermatoses.
- Associated Conditions
- Alopecia, Severe Plaque psoriasis, Corticosteroid responsive, Inflammatory Dermatosis, Corticosteroid responsive, pruritic Dermatosis, Moderate Plaque psoriasis, Moderate Scalp Psoriasis, Severe Scalp Psoriasis
- Associated Therapies
- -
Effect of Bifidobacterium Animalis Subsp. Lactis HN019 on Oral Lichen Planus
- Conditions
- Interventions
- First Posted Date
- 2017-12-29
- Last Posted Date
- 2020-03-27
- Lead Sponsor
- University of Sao Paulo
- Target Recruit Count
- 22
- Registration Number
- NCT03386643
- Locations
- 🇧🇷
School of Dentistry of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Topical Betamethasone and Clobetasol in Orabase in Oral Lichen Planus
- Conditions
- Interventions
- First Posted Date
- 2017-01-20
- Last Posted Date
- 2018-03-14
- Lead Sponsor
- Garlapati Komali
- Target Recruit Count
- 30
- Registration Number
- NCT03026478
- Locations
- 🇮🇳
Komali Garlapati, Hyderabad, Telangana, India
BAY1003803 Formulation Comparison in Open Psoriasis Plaque Test
- Conditions
- Interventions
- First Posted Date
- 2016-10-20
- Last Posted Date
- 2017-03-21
- Lead Sponsor
- Bayer
- Target Recruit Count
- 23
- Registration Number
- NCT02940002
BAY1003803 Single and Multiple Dose Escalation, Safety, Tolerability and Pharmacokinetics Study
- First Posted Date
- 2016-10-18
- Last Posted Date
- 2017-11-08
- Lead Sponsor
- Bayer
- Target Recruit Count
- 32
- Registration Number
- NCT02936492
Comparative Effectiveness Trial in the Treatment of Pediatric Plaque Morphea
- Conditions
- Interventions
- First Posted Date
- 2016-02-11
- Last Posted Date
- 2018-07-18
- Lead Sponsor
- Medical College of Wisconsin
- Registration Number
- NCT02680717
Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity Laser
- Conditions
- Interventions
- First Posted Date
- 2015-04-15
- Last Posted Date
- 2017-10-26
- Lead Sponsor
- Daniela de Fátima Teixeira da Silva
- Target Recruit Count
- 30
- Registration Number
- NCT02416531
- Locations
- 🇧🇷
Hospital Pérola Byington, São Paulo, SP, Brazil
Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer
- Conditions
- Interventions
- First Posted Date
- 2015-02-23
- Last Posted Date
- 2023-07-27
- Lead Sponsor
- Academic and Community Cancer Research United
- Target Recruit Count
- 123
- Registration Number
- NCT02368886
- Locations
- 🇺🇸
Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
🇺🇸Mayo Clinic Hospital, Phoenix, Arizona, United States
🇺🇸Mayo Clinic in Arizona, Scottsdale, Arizona, United States
Comparison Between Corticosteroid and Topical Steroids in the DRESS
- Conditions
- Interventions
- First Posted Date
- 2013-11-19
- Last Posted Date
- 2015-07-30
- Lead Sponsor
- Assistance Publique - Hôpitaux de Paris
- Target Recruit Count
- 112
- Registration Number
- NCT01987076
- Locations
- 🇫🇷
Henri Mondor Hospital, Creteil, France
Clinical Trial With Clobetasol and Dexamethasone for Topical Treatment of Oral Lesions of Chronic Graft-versus-host Disease
- Conditions
- Interventions
- First Posted Date
- 2012-10-03
- Last Posted Date
- 2012-10-03
- Target Recruit Count
- 28
- Registration Number
- NCT01699412
- Locations
- 🇧🇷
Hematology and Hemotherapy Center, Campinas, São Paulo, Brazil
🇧🇷Clementino Fraga Filho University Hospital, Rio de Janeiro, Brazil
A Trial of Clobetasol Propionate Versus Hydrocortisone in Children With Alopecia Areata
- Conditions
- Interventions
- First Posted Date
- 2011-10-18
- Last Posted Date
- 2013-12-09
- Lead Sponsor
- The Hospital for Sick Children
- Target Recruit Count
- 41
- Registration Number
- NCT01453686
- Locations
- 🇨🇦
The Hospital for Sick Children, Toronto, Ontario, Canada
Drug Development Updates
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