Fludarabine
- Generic Name
- Fludarabine
- Brand Names
- Fludara
- Drug Type
- Small Molecule
- Chemical Formula
- C10H12FN5O4
- CAS Number
- 21679-14-1
- Unique Ingredient Identifier
- P2K93U8740
- Background
Fludarabine is a chemotherapeutic agent used in the treatment of hematological malignancies. It is commonly marketed under the brand name Fludara.
- Indication
For the treatment of adult patients with B-cell chronic lymphocytic leukemia (CLL) who have not responded to or whose disease has progressed during treatment with at least one standard alkylating-agent containing regimen
- Associated Conditions
- B-cell chronic lymphocytic leukemia/prolymphocytic leukemia/small lymphocytic lymphoma refractory, Refractory Non-Hodgkin's lymphoma
- Associated Therapies
- -
Advancements in CLL: CAR T, BTK Inhibitors and Personalized Medicine
BTK inhibitors and BCL-2 inhibitors have replaced chemotherapy in CLL treatment, with personalized medicine like mutation and MRD testing guiding care. CAR T-cell therapy and pirtobrutinib offer new options for resistant patients. Future research aims for a cure, explores bispecific T-cell engagers, and uses MRD testing for decision-making.
Drug Development Updates
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