Overview
Horse chestnut is a flowering plant commonly referred to as Aesculus hippocastanum. Unprocessed horse chestnut seeds contain a toxin called esculin (also spelled aesculin) that increases the risk of bleeding due to anticoagulant actions. These seeds are processed to remove the toxic component, resulting in purified horse chestnut seed extract (HCSE) . The active component of this pure extract is escin, or aescin, that promotes blood circulation through the veins and reduces swelling and inflammation of the legs. Its therapeutic potential in the treatment of chronic venous insufficiency is being studied.
Indication
No indication information available.
Associated Conditions
- Back Pain Lower Back
- Back pain
- Cervical Syndrome
- Contusions
- Haemorrhoids
- Sciatica
- Thrombophlebitis
- Trigger Finger Disorder
- Vessels; Varicose
- Hematomas
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|
No clinical trials found
No clinical trials found for this drug
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
|---|---|---|---|---|---|
| King Bio Inc. | 57955-6031 | ORAL | 10 [hp_X] in 59 mL | 5/23/2025 | |
| King Bio Inc. | 57955-2822 | ORAL | 10 [hp_X] in 59 mL | 5/20/2025 | |
| King Bio Inc. | 57955-6163 | ORAL | 10 [hp_X] in 59 mL | 5/19/2025 |
EMA Drug Approvals
Approved Product | Authorization Holder | Status | Issued Date |
|---|---|---|---|
| No EMA approvals found for this drug. | |||
HSA Drug Approvals
Approved Product | Manufacturer | Approval Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
|---|---|---|---|---|---|
| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
|---|---|---|---|---|---|
| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
|---|---|---|---|---|---|
| Leg Veins Support | 482767 | Medicine | A | 3/17/2025 | |
| SleepDrops for Kids | 356123 | Medicine | A | 3/3/2021 | |
| Hair, Skin and Nails | 398237 | Medicine | A | 10/24/2022 | |
| MediHerb Horsechestnut Complex | 214424 | Medicine | A | 9/11/2013 | |
| Caruso's Veins Care Cream | 234772 | Medicine | A | 3/11/2015 | |
| Nature's Sunshine Vari-Gone | 393510 | Medicine | A | 8/5/2022 | |
| Rest&Quiet Sleep Formula | 350161 | Medicine | A | 11/30/2020 | |
| Rest&Quiet Calm Formula | 350160 | Medicine | A | 11/30/2020 | |
| SleepDrops for Babies | 356164 | Medicine | A | 3/4/2021 | |
| Rescue Sleep | 362072 | Medicine | A | 4/15/2021 |
Health Canada Drug Approvals
Approved Product | Company | DIN | Dosage Form | Strength | Market Date |
|---|---|---|---|---|---|
| AESCULUS COMPOSÉ | dolisos canada inc. | 02236447 | Cream
,
Ointment - Topical | 1 X | 1/5/1998 |
| CUTISITUM | 02236489 | Liquid - Oral | 6 D | 2/6/1998 | |
| SEPIA COMPOSE DPS | laboratoires holis inc. | 01934422 | Drops - Oral | 3 DH / DH | 12/31/1984 |
| POMMADE MIDY | welcker-lyster ltd., division of technilab inc. | 00292591 | Ointment - Rectal | 2.5 G / 100 G | 12/31/1948 |
| AESCULUS HIPPOCASTANUM | dolisos canada inc. | 02234281 | Granules
,
Globules
,
Liquid - Oral | 1 X | 1/5/1998 |
| THROAT | botanical laboratories inc. | 02233409 | Tablet - Oral | 6 X | 4/15/1998 |
| MEDIPLEX 640 - LIQ | mediherb inc. | 02116901 | Liquid - Oral | 6 X / ML | 12/19/1996 |
| HP5 TAB | 01975870 | Tablet - Oral | 3 X | 10/4/1996 | |
| AESCULUS DROPS 1X TO C1000 | thompson's homeopathic supplies ltd. | 00761567 | Drops - Oral | 1 X | 12/31/1988 |
| AESCULUS COMPOSÉ | dolisos canada inc. | 02236442 | Globules
,
Granules
,
Liquid - Oral | 1 X | 1/5/1998 |
CIMA AEMPS Drug Approvals
Approved Product | Company | Registration Number | Pharmaceutical Form | Prescription Type | Status |
|---|---|---|---|---|---|
| CASTAÑO DE INDIAS ARKOPHARMA cápsulas duras | Arkopharma Laboratorios S.A.U. | 74480 | CÁPSULA DURA | Sin Receta | Not Commercialized |
Philippines FDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Philippines FDA approvals found for this drug. | |||||
Saudi SFDA Drug Approvals
Approved Product | Company | License Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Saudi SFDA approvals found for this drug. | |||||
Malaysia NPRA Drug Approvals
Approved Product | Company | Registration Number | Dosage Form | Strength | Approval Date |
|---|---|---|---|---|---|
| No Malaysia NPRA approvals found for this drug. | |||||
UK EMC Drug Information
Medicine Name | MA Holder | MA Number | Pharmaceutical Form | Active Ingredient | Authorization Date |
|---|---|---|---|---|---|
| No UK EMC drug information found for this drug. | |||||
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