Atropine

Generic Name
Atropine
Brand Names
Atnaa, Atropen, Busulfex, Donnatal, Duodote, Enlon-plus, Isopto Atropine, Lomotil, Minims Atropine Sulphate, Motofen, Phenohytro
Drug Type
Small Molecule
Chemical Formula
C17H23NO3
CAS Number
51-55-8
Unique Ingredient Identifier
7C0697DR9I
Background

Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active. Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods. Oral atropine ...

Indication

The intravenous, intramuscular, subcutaneous, intraosseous and endotracheal use of atropine is indicated for the temporary blockade of severe or life-threatening muscarinic effects. The intramuscular use of atropine in the form of a pen injector is indicated for the treatment of poisoning by susceptible organophosphorus nerve agents having cholinesterase act...

Associated Conditions
Amblyopia, Atrioventricular Heart-block, Bradycardia, Bronchospasm, Crying, Detrusor Hyperreflexia, Excessive bronchial secretion, Hypertonic uterine contraction, Hypertonicity of the small intestine, Ocular Inflammation, Parkinsonism, Peptic Ulcer, Poisoning by parasympathomimetics (cholinergics), Poisoning caused by mushrooms, Poisoning caused by organophosphate anticholinesterase nerve agents, Poisoning caused by organophosphorus pesticides, Pylorospasm, Rhinorrhoea, Sinus Bradycardia, Spasms, Toxic effect of organophosphate and carbamate, Hypermobility of the colon, Laughing, Life-threatening muscarinic side effects, Muscarinic side effects, Severe muscarinic side effects
Associated Therapies
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Clinical Trials
Related News

Study of Atropine Sulfate Eye Drops(0.01%) in Treating Near-work-induced Transient Myopia in Children

Phase 3
Completed
Conditions
Myopia
Interventions
Drug: Atropine Sulfate
Drug: Placebo
First Posted Date
2024-11-20
Last Posted Date
2024-11-20
Lead Sponsor
Ocumension Therapeutics (Suzhou) Co., Ltd
Target Recruit Count
148
Registration Number
NCT06697522
Locations
🇨🇳

Beijing Children's Hospital, Capital Medical University, Beijing, China

A Study of SHJ002 Sterile Ophthalmic Solution for Myopia Control

Phase 2
Not yet recruiting
Conditions
Myopia, Progressive
Interventions
Drug: SHJ002
Drug: Atropine
First Posted Date
2024-08-30
Last Posted Date
2024-08-30
Lead Sponsor
Sunhawk Vision Biotech, Inc.
Target Recruit Count
144
Registration Number
NCT06579287
Locations
🇺🇸

Pacific Center for Advanced Vision Care Tanasbourne Vision Center, Hillsboro, Ohio, United States

Dexmedetomidine Infusion Dose Versus Rapid Bolus Dose Before Tracheal Intubation.

First Posted Date
2024-03-25
Last Posted Date
2024-03-25
Lead Sponsor
Kasr El Aini Hospital
Target Recruit Count
70
Registration Number
NCT06327399
Locations
🇪🇬

Cairo University Hospitals, Giza, Egypt

Outcome of Moderate Severity in OPC Poisoning Patients When Treated With Pralidoxime

Phase 2
Completed
Conditions
Organophosphorus Poisoning
Interventions
Drug: Pralidoxime
Drug: Atropine
First Posted Date
2023-11-01
Last Posted Date
2024-10-09
Lead Sponsor
Sir Salimullah Medical College Mitford Hospital
Target Recruit Count
96
Registration Number
NCT06111352
Locations
🇧🇩

Sir Salimullah Medical College Mitford Hospital, Dhaka, Bangladesh

Myopia Control: a Comparison Study Between Atropine and MiSight

Phase 2
Recruiting
Conditions
Myopia
Interventions
Device: MiSight contact lenses
Drug: Atropine
First Posted Date
2023-04-18
Last Posted Date
2024-11-19
Lead Sponsor
Ann & Robert H Lurie Children's Hospital of Chicago
Target Recruit Count
348
Registration Number
NCT05815784
Locations
🇺🇸

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States

Adverse Events Related to Low Dose Atropine

Completed
Conditions
Myopia, Progressive
First Posted Date
2023-01-13
Last Posted Date
2023-04-25
Lead Sponsor
Scripps Health
Target Recruit Count
148
Registration Number
NCT05683535
Locations
🇺🇸

Laura Kirkeby, San Diego, California, United States

Impact of Pre-spinal Atropine on Post Spinal Hemodynamics and Cardiac Output Measured by Electrical Cardiometry in Caesarean Delivery

Phase 3
Completed
Conditions
Anesthesia
Interventions
Drug: Isotonic saline
Drug: atropine
First Posted Date
2022-12-20
Last Posted Date
2023-07-20
Lead Sponsor
Ain Shams University
Target Recruit Count
60
Registration Number
NCT05658380
Locations
🇪🇬

Ain Shams University hospitals, Cairo, Egypt

Safety and Tolerability Evaluation of PRO-230 Ophthalmic Solution

Phase 1
Withdrawn
Conditions
Myopia
Interventions
Drug: Atropine Sulfate
First Posted Date
2022-08-01
Last Posted Date
2024-07-01
Lead Sponsor
Laboratorios Sophia S.A de C.V.
Registration Number
NCT05481489

Phase I Clinical Trial to Evaluate the Safety and Tolerability of Ophtalmic Solution PRO-201

Phase 1
Completed
Conditions
Myopia
Interventions
Drug: Atropine Sulfate
First Posted Date
2022-07-22
Last Posted Date
2023-12-06
Lead Sponsor
Laboratorios Sophia S.A de C.V.
Target Recruit Count
29
Registration Number
NCT05470881
Locations
🇲🇽

IIMET Investigación e Innovación en Medicina Traslacional, Guadalajara, Jalisco, Mexico

Safety, Tolerability and Pharmacodynamics Evaluation of CBT-009 Eye Drop

First Posted Date
2022-05-13
Last Posted Date
2023-01-27
Lead Sponsor
Cloudbreak Therapeutics, LLC
Target Recruit Count
84
Registration Number
NCT05372991
Locations
🇦🇺

USC, Brisbane, Australia

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