Atropine

Generic Name
Atropine
Brand Names
Atnaa, Atropen, Busulfex, Donnatal, Duodote, Enlon-plus, Isopto Atropine, Lomotil, Minims Atropine Sulphate, Motofen, Phenohytro
Drug Type
Small Molecule
Chemical Formula
C17H23NO3
CAS Number
51-55-8
Unique Ingredient Identifier
7C0697DR9I
Background

Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active. Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods. Oral atropine ...

Indication

The intravenous, intramuscular, subcutaneous, intraosseous and endotracheal use of atropine is indicated for the temporary blockade of severe or life-threatening muscarinic effects. The intramuscular use of atropine in the form of a pen injector is indicated for the treatment of poisoning by susceptible organophosphorus nerve agents having cholinesterase act...

Associated Conditions
Amblyopia, Atrioventricular Heart-block, Bradycardia, Bronchospasm, Crying, Detrusor Hyperreflexia, Excessive bronchial secretion, Hypertonic uterine contraction, Hypertonicity of the small intestine, Ocular Inflammation, Parkinsonism, Peptic Ulcer, Poisoning by parasympathomimetics (cholinergics), Poisoning caused by mushrooms, Poisoning caused by organophosphate anticholinesterase nerve agents, Poisoning caused by organophosphorus pesticides, Pylorospasm, Rhinorrhoea, Sinus Bradycardia, Spasms, Toxic effect of organophosphate and carbamate, Hypermobility of the colon, Laughing, Life-threatening muscarinic side effects, Muscarinic side effects, Severe muscarinic side effects
Associated Therapies
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Clinical Trials
Related News

The Effects of Low Dose Atropine on Choroidal Thickness

Phase 4
Completed
Conditions
Myopia
Interventions
Drug: Atropine
First Posted Date
2018-06-04
Last Posted Date
2019-02-15
Lead Sponsor
State University of New York College of Optometry
Target Recruit Count
36
Registration Number
NCT03544827
Locations
πŸ‡ΊπŸ‡Έ

SUNY College of Optometry, New York, New York, United States

Low-Dose Atropine for Treatment of Myopia

Phase 3
Completed
Conditions
Myopia
Interventions
Other: Placebo Eyedrops
Drug: Atropine
First Posted Date
2017-11-07
Last Posted Date
2023-09-05
Lead Sponsor
Jaeb Center for Health Research
Target Recruit Count
200
Registration Number
NCT03334253
Locations
πŸ‡ΊπŸ‡Έ

Vanderbilt University Medical Center - Vanderbilt Eye Institute, Nashville, Tennessee, United States

πŸ‡ΊπŸ‡Έ

Rocky Mountain Eye Care Associates, Salt Lake City, Utah, United States

πŸ‡ΊπŸ‡Έ

University of Alabama at Birmingham, Birmingham, Alabama, United States

and more 10 locations

Effect of Atropine or Glycopyrrolate on the Prevention of Bradycardia During Sedation Using Dexmedetomidine in Adult Patients Undergoing Lower Extremity Surgery Under Spinal Anesthesia

Not Applicable
Terminated
Conditions
Spinal Anesthesia
Interventions
Drug: Atropine
Drug: Glycopyrrolate
First Posted Date
2017-10-26
Last Posted Date
2019-03-14
Lead Sponsor
Yonsei University
Target Recruit Count
2
Registration Number
NCT03322150
Locations
πŸ‡°πŸ‡·

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of

Effect of Atropine or Glycopyrrolate on the Prevention of Bradycardia During Sedation Using Dexmedetomidine in Geriatric Patients Undergoing Total Knee Replacement Under Spinal Anesthesia

Not Applicable
Completed
Conditions
Spinal Anesthesia
Interventions
Drug: Atropine
Drug: Glycopyrrolate
First Posted Date
2017-10-26
Last Posted Date
2018-09-24
Lead Sponsor
Yonsei University
Target Recruit Count
54
Registration Number
NCT03322098
Locations
πŸ‡°πŸ‡·

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea, Republic of

Atropine in Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)

First Posted Date
2016-10-06
Last Posted Date
2020-01-28
Lead Sponsor
Vanderbilt University
Target Recruit Count
6
Registration Number
NCT02927223
Locations
πŸ‡ΊπŸ‡Έ

Vanderbilt University, Nashville, Tennessee, United States

The Effects of Low Concentration Atropine on Pupil Size and Accommodation

Phase 3
Completed
Conditions
Myopia
Interventions
Drug: Atropine
First Posted Date
2016-08-17
Last Posted Date
2020-11-04
Lead Sponsor
University of California, Berkeley
Target Recruit Count
32
Registration Number
NCT02870478
Locations
πŸ‡ΊπŸ‡Έ

UC Berkeley, Department of Vision Science, Berkeley, California, United States

The Impact of Intravenous Anaesthesia on Angiogenesis in Patients With Breast Cancer (TIVA/TCI-BC)

First Posted Date
2016-07-21
Last Posted Date
2019-10-29
Lead Sponsor
Iuliu Hatieganu University of Medicine and Pharmacy
Target Recruit Count
120
Registration Number
NCT02839668
Locations
πŸ‡·πŸ‡΄

IOCN Prof Dr I chiricuta, Cluj-Napoca, Romania

The Effects of Bariatric Surgeries on Glucose Metabolism

First Posted Date
2016-07-06
Last Posted Date
2024-08-28
Lead Sponsor
The University of Texas Health Science Center at San Antonio
Target Recruit Count
200
Registration Number
NCT02823665
Locations
πŸ‡ΊπŸ‡Έ

South Texas Veterans Health Care System, San Antonio, Texas, United States

πŸ‡ΊπŸ‡Έ

Texas Diabetes Institute - University Health System, San Antonio, Texas, United States

Atropine in Laparoscopic Gynaecological Surgery

First Posted Date
2016-05-11
Last Posted Date
2016-05-11
Lead Sponsor
Clinica Santa Maria
Target Recruit Count
150
Registration Number
NCT02769325
Locations
πŸ‡¨πŸ‡±

Clinica Santa Maria, Santiago, Chile

Decision Support for Intraoperative Low Blood Pressure

Not Applicable
Completed
Conditions
Hypotension
Interventions
Procedure: Attending real-time decision support
Procedure: In-room real-time decision support
Procedure: Attending feedback emails
Procedure: In-room provider feedback emails
Device: Anesthesia Information Management System (AIMS)
Device: Perioperative Data Warehouse (PDW)
Procedure: General anesthesia
Device: Pager system
Procedure: Central neuraxial anesthesia
Procedure: Non-cardiac surgery
Drug: Propofol
Drug: Sevoflurane
Drug: Desflurane
Drug: Isoflurane
Drug: Ephedrine
Drug: Phenylephrine
Drug: Norepinephrine
Drug: Epinephrine
Drug: Dobutamine
Drug: Dopamine
Drug: Isoproterenol
Drug: Milrinone
Drug: Atropine
Drug: Glycopyrrolate
Drug: Vasopressin
Drug: Terlipressin
Drug: Sodium Chloride 0.9%
Drug: Ringer's lactate
Drug: Hydroxyethyl starch solutions
Drug: Fresh Frozen Plasma
Drug: Packed Red Blood Cells
Drug: Albumin solutions
Drug: Plasma-Lyte
Drug: Lidocaine
Drug: Bupivacaine
Drug: Levobupivacaine
Drug: Ropivacaine
Drug: Mepivacaine
Drug: Tetracaine
Drug: Prilocaine
Drug: Procaine
Drug: Chloroprocaine
Drug: Benzocaine
Drug: Articaine
First Posted Date
2016-04-04
Last Posted Date
2019-05-16
Lead Sponsor
Vanderbilt University Medical Center
Target Recruit Count
22435
Registration Number
NCT02726620
Locations
πŸ‡ΊπŸ‡Έ

Vanderbilt University Medical Center, Nashville, Tennessee, United States

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