Overview
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Indication
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Research Report
An Expert Report on WDB-178: A Preclinical Investigational Agent Targeting KRAS G12C
1. Executive Summary
WDB-178 is an investigational therapeutic agent in the preclinical phase of development, originated by Revolution Medicines, Inc..[1] It is classified as a non-degrading molecular glue and is designed to target the oncogenic KRAS G12C protein, a well-validated driver in various human cancers. The mechanism of action of WDB-178 is understood to be as a KRAS G12C inhibitor, operating through Revolution Medicines' proprietary tri-complex inhibitor platform.[2] This platform distinctively targets the active, GTP-bound conformation of RAS proteins, commonly referred to as RAS(ON). The therapeutic strategy involves inducing the formation of a ternary complex comprising WDB-178, an intracellular chaperone protein (such as cyclophilin A), and the RAS(ON) target protein. This tri-complex formation is intended to sterically hinder the interaction of KRAS G12C(ON) with its downstream effector proteins, thereby abrogating oncogenic signaling pathways.[4]
Clinical Trials
Title | Posted | Study ID | Phase | Status | Sponsor |
|---|---|---|---|---|---|
2023/12/08 | Phase 1 | Recruiting | |||
2022/07/18 | Phase 1 | Active, not recruiting |
FDA Drug Approvals
Approved Product | Manufacturer | NDC Code | Route | Strength | Effective Date |
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| No FDA approvals found for this drug. | |||||
EMA Drug Approvals
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| No EMA approvals found for this drug. | |||
HSA Drug Approvals
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| No HSA approvals found for this drug. | |||||
NMPA Drug Approvals
Approved Product | Company | Approval Number | Drug Type | Dosage Form | Approval Date |
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| No NMPA approvals found for this drug. | |||||
PPB Drug Approvals
Approved Product | Registration No. | Company | Licence No. | Strength | Registration Date |
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| No PPB approvals found for this drug. | |||||
TGA Drug Approvals
Approved Product | ARTG ID | Sponsor | Registration Type | Status | Registration Date |
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| No TGA approvals found for this drug. | |||||
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