Pathogen-specific aAPC
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Through analysis of potential immunogenic targets of the SARS-Cov2 genome, a synthetic ‘minigene’ was developed using domains of viral structural proteins and a polyprotein protease. Specifically, the COVID-19 infection relies on the binding of the Spike protein to an ACEII receptor, and with the described approach, the vaccine uses these engineered minigenes to express viral proteins, modify artificial antigen presenting cells (aAPC), and activate T-cells. As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials.
Through analysis of potential immunogenic targets of the SARS-Cov2 genome, a synthetic ‘minigene’ was developed using domains of viral structural proteins and a polyprotein protease. Specifically, the COVID-19 infection relies on the binding of the Spike protein to an ACEII receptor, and with the described approach, the vaccine uses these engineered minigenes to express viral proteins, modify artificial antigen presenting cells (aAPC), and activate T-cells. As of August 2020, this vaccine is being tested for prophylaxis against COVID-19 in human clinical trials.
