甲氧沙林 (Oxsoralen, Uvadex)

概览

Methoxsalen is a furocoumarin used to treat psoriasis and vitiligo.

作用机制

After activation it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.

适应症

For the treatment of psoriasis and vitiligo

• Cutaneous T-Cell Lymphoma (CTCL)
• Refractory Cutaneous T-cell Lymphoma
• Vitiligo
• Idiopathic Vitiligo
• Severe Psoriasis