Methoxsalen

Generic Name
Methoxsalen
Brand Names
Oxsoralen, Uvadex
Drug Type
Small Molecule
Chemical Formula
C12H8O4
CAS Number
298-81-7
Unique Ingredient Identifier
U4VJ29L7BQ
Background

A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation.

Indication

For the treatment of psoriasis and vitiligo

Associated Conditions
Cutaneous T-Cell Lymphoma (CTCL), Refractory Cutaneous T-cell Lymphoma, Vitiligo, Idiopathic Vitiligo, Severe Psoriasis
Associated Therapies
-

EPIC- Extracorporeal Photopheresis (ECP) for Immune-related Colitis

Phase 2
Not yet recruiting
Conditions
Interventions
First Posted Date
2024-10-17
Last Posted Date
2024-11-07
Lead Sponsor
Therakos, LLC, a Mallinckrodt Company
Target Recruit Count
30
Registration Number
NCT06646016

Steroids Versus ECP and Steroids as First-line Treatment of Grade II Acute GVHD

Phase 2
Not yet recruiting
Conditions
Interventions
First Posted Date
2023-11-15
Last Posted Date
2023-11-15
Lead Sponsor
Central Hospital, Nancy, France
Target Recruit Count
42
Registration Number
NCT06133192
Locations
🇫🇷

CHRU de Nancy, Vandoeuvre Les Nancy, France

Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis

First Posted Date
2021-08-03
Last Posted Date
2024-11-25
Lead Sponsor
Lawson Health Research Institute
Target Recruit Count
15
Registration Number
NCT04986605
Locations
🇨🇦

Rheumatology Clinic, St. Joseph's Health Care, London, Ontario, Canada

Extracorporal Photopheresis With UVADEX Plus Standard Steroid Treatment for High Risk Acute Graft-versus-host Disease

Phase 2
Recruiting
Conditions
Interventions
First Posted Date
2020-03-02
Last Posted Date
2024-02-09
Lead Sponsor
Universitätsklinikum Hamburg-Eppendorf
Target Recruit Count
72
Registration Number
NCT04291261
Locations
🇦🇹

Medical University of Vienna, Department of Medicine I, Vienna, Austria

🇦🇹

Medical University of Graz, Department of Internal Medicine, Graz, Austria

🇩🇪

University Hospital Erlangen, Erlangen, Germany

and more 2 locations

Study of Photopheresis in the Treatment of Erythrodermic MF and SS

First Posted Date
2018-06-20
Last Posted Date
2021-09-08
Lead Sponsor
European Organisation for Research and Treatment of Cancer - EORTC
Registration Number
NCT03563040
Locations
🇨🇭

UniversitaetsSpital Zurich - Division of Dermatology, Zürich, Switzerland

Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease

First Posted Date
2015-08-17
Last Posted Date
2020-09-11
Lead Sponsor
Therakos, Inc., a Mallinckrodt Company
Target Recruit Count
29
Registration Number
NCT02524847
Locations
🇺🇸

Hackensack University Medical Center, Hackensack, New Jersey, United States

🇺🇸

Boston Children's Hospital, Boston, Massachusetts, United States

🇺🇸

University Hospitals Rainbow Babies & Children's, Cleveland, Ohio, United States

and more 29 locations

Biomarkers in Acute Graft-Versus-Host Disease and Extracorporeal Photopheresis Added to Investigator Chosen Therapies of Steroid Refractory Acute GVHD

First Posted Date
2014-12-23
Last Posted Date
2020-03-12
Lead Sponsor
National Cancer Institute (NCI)
Target Recruit Count
5
Registration Number
NCT02322190
Locations
🇺🇸

National Institutes of Health Clinical Center, 9000 Rockville Pike, Bethesda, Maryland, United States

PUVA Maintenance Therapy in Mycosis Fungoides

First Posted Date
2012-09-18
Last Posted Date
2018-11-14
Lead Sponsor
Medical University of Graz
Target Recruit Count
28
Registration Number
NCT01686594
Locations
🇦🇹

Department of Dermatology, Medical University of Vienna, Vienna, Austria

🇦🇹

Department of Dermatology, Hospital Hietzing, Vienna, Austria

🇦🇹

Department of Dermatology, Klinikum Wels, Wels, Austria

and more 6 locations

Extracorporal Photopheresis Pilot Study

First Posted Date
2009-06-30
Last Posted Date
2013-04-24
Lead Sponsor
Hospices Civils de Lyon
Target Recruit Count
20
Registration Number
NCT00930566
Locations
🇫🇷

Centre de Santé - Etablissement Français du Sang (EFS), Lyon, France

🇫🇷

Hôpital Edouard Herriot, Service d'Hématologie, Lyon, France

Addition of Etanercept and Extracorporeal Photopheresis (ECP) to Standard Graft-Versus-Host Disease (GVHD) Prophylaxis in Stem Cell Transplant

First Posted Date
2008-03-20
Last Posted Date
2017-08-01
Lead Sponsor
University of Michigan Rogel Cancer Center
Target Recruit Count
48
Registration Number
NCT00639717
Locations
🇺🇸

University of Michigan Cancer Center, Ann Arbor, Michigan, United States

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