Prasugrel
- Generic Name
- Prasugrel
- Brand Names
- Effient, Efient, Prasugrel Viatris (previously Prasugrel Mylan)
- Drug Type
- Small Molecule
- Chemical Formula
- C20H20FNO3S
- CAS Number
- 150322-43-3
- Unique Ingredient Identifier
- 34K66TBT99
- Background
Prasugrel, a thienopyridine derivative, is a platelet activation and aggregation inhibitor structurally and pharmacologically related to clopidogrel and ticlopidine. Similar to clopidogrel, prasugrel is a prodrug that requires enzymatic transformation in the liver to its active metabolite, R-138727. R-138727 irreversibly binds to P2Y12 type ADP receptors on ...
- Indication
用于心力衰竭、卒中、不稳定心绞痛等心脑血管疾病以及有急性冠状动脉综合征需要进行经皮冠脉介入术的患者。
- Associated Conditions
- Cardiovascular Events
- Associated Therapies
- -
Prasugrel in Comparison to Clopidogrel for Inhibition of Platelet Reactivity in Patients With ST-elevation Myocardial Infarction (STEMI)
- First Posted Date
- 2011-04-20
- Last Posted Date
- 2011-09-30
- Lead Sponsor
- University of Patras
- Target Recruit Count
- 35
- Registration Number
- NCT01338909
- Locations
- 🇬🇷
Patras University Hospital, Patras, Greece
Evaluating Additional Platelet Inhibition in Patients With High Platelet Reactivity Undergoing Percutaneous Coronary Intervention
- Conditions
- Interventions
- First Posted Date
- 2011-04-20
- Last Posted Date
- 2014-09-18
- Lead Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
- Target Recruit Count
- 44
- Registration Number
- NCT01339026
- Locations
- 🇩🇪
Universitätsklinikum Tübingen, Tübingen, Germany
Facilitation Through Aggrastat By drOpping or Shortening Infusion Line in Patients With ST-segment Elevation Myocardial Infarction Compared to or on Top of PRasugrel Loading dOse
- Conditions
- Interventions
- First Posted Date
- 2011-04-15
- Last Posted Date
- 2012-10-10
- Lead Sponsor
- Università degli Studi di Ferrara
- Target Recruit Count
- 100
- Registration Number
- NCT01336348
- Locations
- 🇮🇹
Cardiology Unit, Ferrara, Italy
Early Thienopyridine Treatment to Improve Primary PCI in Patients With Acute MI
- First Posted Date
- 2011-04-01
- Last Posted Date
- 2016-06-17
- Lead Sponsor
- Stiftung Institut fuer Herzinfarktforschung
- Target Recruit Count
- 63
- Registration Number
- NCT01327534
- Locations
- 🇩🇪
Klinikum Ludwigshafen, Med. Klinik B, Ludwigshafen, Germany
🇩🇪Charité Campus Benjamin Franklin, Med. Klinik II, Berlin, Germany
🇫🇷Hospital Pitie-Salpetriere, Paris, France
The Effect of Prasugrel on Bronchial Hyperreactivity and on Markers of Inflammation in Patients With Chronic Asthma
- Conditions
- First Posted Date
- 2011-02-28
- Last Posted Date
- 2012-03-06
- Lead Sponsor
- University of Milan
- Target Recruit Count
- 26
- Registration Number
- NCT01305369
- Locations
- 🇮🇹
Medicina 3 Ospedale San Paolo Dipartimento di Medicina Chirurgia e Odontoiatria, Università di Milano, Milan, Italy
Prasugrel Versus High Dose Clopidogrel in Patients With Stable Coronary Artery Disease and High Platelet Reactivity While on Chronic Clopidogrel Treatment
- Conditions
- Interventions
- First Posted Date
- 2011-02-25
- Last Posted Date
- 2011-08-23
- Lead Sponsor
- University of Patras
- Target Recruit Count
- 25
- Registration Number
- NCT01304472
- Locations
- 🇬🇷
Dimitrios Alexopoulos, Patras, Greece
🇬🇷Patras University Hospital Cardiology Department, Patras, Greece
The Influence of Smoking Status on Prasugrel and Clopidogrel Treated Subjects Taking Aspirin and Having Stable Coronary Artery Disease
- First Posted Date
- 2010-12-15
- Last Posted Date
- 2019-01-09
- Lead Sponsor
- Daiichi Sankyo
- Target Recruit Count
- 110
- Registration Number
- NCT01260584
- Locations
- 🇺🇸
Medpace Clinical Pharmacology Unit, Cincinnati, Ohio, United States
🇺🇸The Carl and Edyth Lindner Center for Research and Education at the Christ Hospital, Cincinnati, Ohio, United States
🇺🇸Sanai Center for Thrombosis Research, Baltimore, Maryland, United States
Prasugrel Re-load Strategies
- First Posted Date
- 2010-09-15
- Last Posted Date
- 2013-01-18
- Lead Sponsor
- University of Florida
- Target Recruit Count
- 65
- Registration Number
- NCT01201772
- Locations
- 🇺🇸
University of Florida, Jacksonville, Florida, United States
An Assessment of Prasugrel on Healthy Adults and Sickle Cell Adults
- First Posted Date
- 2010-08-09
- Last Posted Date
- 2012-02-15
- Lead Sponsor
- Eli Lilly and Company
- Target Recruit Count
- 26
- Registration Number
- NCT01178099
- Locations
- 🇬🇧
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician., London, UK, United Kingdom
Double the Dose of Clopidogrel or Switch to Prasugrel to Antagonize Proton Pump Inhibitor Interaction.
- Conditions
- Interventions
- First Posted Date
- 2010-08-04
- Last Posted Date
- 2012-07-04
- Lead Sponsor
- Ascopharm Groupe Novasco
- Target Recruit Count
- 82
- Registration Number
- NCT01175200
- Locations
- 🇫🇷
Pitié Salpétrière Hospital, Paris, France
Drug Development Updates
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