Floxuridine
- Generic Name
- Floxuridine
- Drug Type
- Small Molecule
- Chemical Formula
- C9H11FN2O5
- CAS Number
- 50-91-9
- Unique Ingredient Identifier
- 039LU44I5M
- Background
An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection. Floxuridine is available as a sterile, nonpyrogenic, lyophilized powder for reconstitution. When administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.
- Indication
For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means. Also for the palliative management of liver cancer (usually administered by hepatic intra-arterial infusion).
- Associated Conditions
- Stage 4 gastrointestinal adenocarcinoma
- Associated Therapies
- Palliative Treatment
A Study of the Use of the Medtronic Pump and Codman Catheter to Give Chemotherapy to Patients With Colorectal Carcinoma or Cholangiocarcinoma
- Conditions
- Colorectal CancerCholangiocarcinoma
- Interventions
- Device: Medtronic pump and Codman catheterDrug: Anti-EGFR (Panitumumab or Cetuximab)
- First Posted Date
- 2018-10-03
- Last Posted Date
- 2024-07-01
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Target Recruit Count
- 35
- Registration Number
- NCT03693807
- Locations
- 🇺🇸
Memorial Sloan Kettering Monmouth, Middletown, New Jersey, United States
🇺🇸Memorial Sloan Kettering Commack, Commack, New York, United States
🇺🇸Memorial Sloan Kettering Cancer Center, New York, New York, United States
FUDR/Oxaliplatin HAI Plus Irinotecan vs. FOLFOXIRI Chemotherapy in Treating Initially Unresectable CRCLM
- Conditions
- Liver MetastasesMetastatic Colorectal Cancer
- Interventions
- First Posted Date
- 2018-09-19
- Last Posted Date
- 2023-02-16
- Lead Sponsor
- Sun Yat-sen University
- Target Recruit Count
- 92
- Registration Number
- NCT03678428
- Locations
- 🇨🇳
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
A Study of Systemic Chemotherapy With CPT-11 Plus HAI (FUDR+L-OHP) in Patients With Initially Unresectable CRCLM
- Conditions
- Colo-rectal CancerLiver Metastases
- Interventions
- First Posted Date
- 2018-04-10
- Last Posted Date
- 2023-02-15
- Lead Sponsor
- Sun Yat-sen University
- Target Recruit Count
- 60
- Registration Number
- NCT03493061
- Locations
- 🇨🇳
Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
Study of Chemotherapy With or Without Hepatic Arterial Infusion for Patients With Unresectable Metastatic Colorectal Cancer to the Liver
- Conditions
- Colorectal Adenocarcinoma Metastatic to the Liver
- Interventions
- First Posted Date
- 2017-03-03
- Last Posted Date
- 2019-05-21
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Registration Number
- NCT03069950
- Locations
- 🇺🇸
Memorial Sloan Kettering Commack, Commack, New York, United States
🇺🇸Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey, United States
🇺🇸Memoral Sloan Kettering Westchester, Harrison, New York, United States
Alternating Systemic and Hepatic Artery Infusion Therapy As Adjuvant Treatment After Resection of Liver Metastases From Colorectal Cancer
- Conditions
- Resected Liver Metastases From Colorectal Cancer
- Interventions
- First Posted Date
- 2015-08-20
- Last Posted Date
- 2015-08-20
- Lead Sponsor
- Ye Xu
- Target Recruit Count
- 432
- Registration Number
- NCT02529774
- Locations
- 🇨🇳
Fudan University Shanghai Cancer Center China, Shanghai, Shanghai, China
Hepatic Arterial Infusion With Floxuridine and Dexamethasone in Combination With Gemcitabine as Adjuvant Treatment After Resection of Intrahepatic Cholangiocarcinoma
- Conditions
- Intrahepatic CholangiocarcinomaPeripheral CholangiocarcinomaCholangiocellular Carcinoma) (ICC)Cholangiolar Carcinoma
- Interventions
- Procedure: Liver resection and placement of hepatic artery infusion pump
- First Posted Date
- 2013-09-10
- Last Posted Date
- 2020-09-11
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Target Recruit Count
- 8
- Registration Number
- NCT01938729
- Locations
- 🇺🇸
Memorial Sloan Kettering Cancer Center at Commack, Commack, New York, United States
🇺🇸Memorial Sloan Kettering Cancer Center at Basking Ridge, Basking Ridge, New Jersey, United States
🇺🇸Memorial Sloan Kettering Cancer Center, New York, New York, United States
Hepatic Arterial Infusion (HAI) With Floxuridine (FUDR) and Dexamethasone (Dex) Combined With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma (ICC)
- Conditions
- Cholangiolar CarcinomaCholangiocellular CarcinomaPeripheral CholangiocarcinomaIntrahepatic Cholangiocarcinoma
- Interventions
- Other: MRIOther: Research blood draws
- First Posted Date
- 2013-05-24
- Last Posted Date
- 2025-03-19
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Target Recruit Count
- 55
- Registration Number
- NCT01862315
- Locations
- 🇺🇸
Memorial Sloan Kettering Commack, Commack, New York, United States
🇺🇸Memorial Sloan Kettering Westchester, Harrison, New York, United States
🇺🇸Memorial Sloan Kettering Nassau, Uniondale, New York, United States
Veliparib and Floxuridine in Treating Patients With Metastatic Epithelial Ovarian, Primary Peritoneal Cavity, or Fallopian Tube Cancer
- Conditions
- Stage IV Ovarian Cancer AJCC v6 and v7Stage IV Primary Peritoneal Cancer AJCC v7Stage IV Fallopian Tube Cancer AJCC v6 and v7
- Interventions
- First Posted Date
- 2012-12-13
- Last Posted Date
- 2020-07-02
- Lead Sponsor
- National Cancer Institute (NCI)
- Target Recruit Count
- 29
- Registration Number
- NCT01749397
- Locations
- 🇺🇸
Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore, Maryland, United States
🇺🇸Mayo Clinic in Rochester, Rochester, Minnesota, United States
🇺🇸Siteman Cancer Center at Washington University, Saint Louis, Missouri, United States
Hepatic Arterial Infusion in Treating Patients With Locally Advanced, Non-Metastatic Cholangiocarcinoma
- Conditions
- CholangiocarcinomaLiver Neoplasms
- Interventions
- First Posted Date
- 2012-02-02
- Last Posted Date
- 2022-08-10
- Lead Sponsor
- Washington University School of Medicine
- Target Recruit Count
- 27
- Registration Number
- NCT01525069
- Locations
- 🇺🇸
Washington University School of Medicine, Saint Louis, Missouri, United States
Adjuvant Intraperitoneal Floxuridine Added to Chemoradiation for Fully Resected Advanced Stomach Cancer
- Conditions
- Gastric CancerStomach Cancer
- First Posted Date
- 2009-03-09
- Last Posted Date
- 2016-03-11
- Lead Sponsor
- NYU Langone Health
- Target Recruit Count
- 28
- Registration Number
- NCT00858338
- Locations
- 🇺🇸
Bellevue Hospital, New York, New York, United States
🇺🇸NYU Tisch Hospital, New York, New York, United States
🇺🇸NYU Cancer Center, New York, New York, United States
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