Famciclovir

Generic Name: Famciclovir

Brand Names: Famvir

Drug Type: Small Molecule

Chemical Formula: C_₁₄H_₁₉N_₅O_₄

CAS Number: 104227-87-4

Unique Ingredient Identifier: QIC03ANI02

Background: Famciclovir, marketed as Famvir by Novartis, is a guanine analogue used to treat herpes virus infections. It is most commonly used to treat herpes zoster (shingles). Famciclovir is a prodrug of penciclovir with higher oral bioavailability.

Indication: For the treatment of acute herpes zoster (shingles). Also for the treatment or suppression of recurrent genital herpes in immunocompetent patients and treatment of recurrent mucocutaneous herpes simplex infections in HIV infected patients.

Associated Conditions: Herpes Zoster, Recurrent Genital Herpes (RGH), Recurrent Herpes Labialis

Associated Therapies: -

Clinical Trials

Famciclovir in Multiple Sclerosis

Phase 2

Conditions: Multiple Sclerosis

Interventions: Drug: Famciclovir

First Posted Date: 2022-03-17

Last Posted Date: 2022-03-17

Lead Sponsor: Queen Mary University of London

Target Recruit Count: 30

Registration Number: NCT05283551

Locations: 🇬🇧
Royal London Hospital, Barts Health NHS Trust, London, United Kingdom

Effect of Early Use of Oxycodone During the Acute Phase of Herpes Zoster on Preventing Postherpetic Neuralgia

Not Applicable

Conditions: Herpes Zoster
Post-herpetic Neuralgia

Interventions: Drug: Oxycodone
Drug: Gabapentin
Drug: Famciclovir

First Posted Date: 2017-04-19

Last Posted Date: 2017-04-19

Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Target Recruit Count: 140

Registration Number: NCT03120962

Famvir for Treatment of Hearing in Unilateral Meniere's Disease

Phase 3

Terminated

Conditions: Meniere's Disease

Interventions: Drug: Placebo
Drug: Famciclovir

First Posted Date: 2012-02-03

Last Posted Date: 2021-04-19

Lead Sponsor: House Research Institute

Target Recruit Count: 11

Registration Number: NCT01526408

Efficacy of Oral Famciclovir Versus Aciclovir Treatment in Patients With Herpes Zoster

Phase 3

Completed

Conditions: Herpes Zoster

Interventions: Drug: Famciclovir
Drug: Aciclovir

First Posted Date: 2011-04-01

Last Posted Date: 2019-04-17

Lead Sponsor: EMS

Target Recruit Count: 177

Registration Number: NCT01327144

Locations: 🇧🇷
Allergisa, Campinas, São Paulo, Brazil
🇧🇷
Centro de Medicina Reprodutiva Dr Carlos Isaia Filho, Porto Alegre, RS, Brazil
🇧🇷
Loema, Campinas, SP, Brazil

and more 2 locations

Bioequivalency Study of Famciclovir 500 mg Tablets Under Fed Conditions

Not Applicable

Completed

Conditions: Herpes

First Posted Date: 2011-03-23

Last Posted Date: 2018-01-23

Lead Sponsor: Roxane Laboratories

Target Recruit Count: 31

Registration Number: NCT01321502

Locations: 🇺🇸
Advanced Biomedical Research, Hackensack, New Jersey, United States

Bioequivalency Study of Famciclovir 500 mg Tablets Under Fasted Conditions

Not Applicable

Completed

Conditions: Herpes

First Posted Date: 2011-03-23

Last Posted Date: 2018-01-23

Lead Sponsor: Roxane Laboratories

Target Recruit Count: 36

Registration Number: NCT01321515

Locations: 🇺🇸
Advanced Biomedical Research, Inc., Hackensack, New Jersey, United States

Efficacy of Oral Famciclovir 125mg Comparing to Aciclovir 200 mg Treatment in Patients With Active Recurrent Genital Herpes

Phase 3

Completed

Conditions: GENITAL HERPES

Interventions: Drug: Famciclovir
Drug: Aciclovir

First Posted Date: 2011-01-21

Last Posted Date: 2021-04-21

Lead Sponsor: EMS

Target Recruit Count: 150

Registration Number: NCT01281007

Locations: 🇧🇷
Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil
🇧🇷
Caep Centro Avancado de Estudos E Pesquisas Ltda, Campinas, SP, Brazil
🇧🇷
Centro de Medicina Reprodutiva Dr Carlos Isaia Filho Ltda, Porto Alegre, RS, Brazil

and more 6 locations

Safety and Pharmacokinetics of Famciclovir Single 1500 mg Dose in Adolescents With Recurrent Herpes Labialis

Phase 2

Completed

Conditions: Herpes Labialis

Interventions: Drug: Famciclovir

First Posted Date: 2009-04-08

Last Posted Date: 2021-06-25

Lead Sponsor: Novartis Pharmaceuticals

Target Recruit Count: 53

Registration Number: NCT00878072

Locations: 🇺🇸
Westover Heights Clinic, Portland, Oregon, United States
🇺🇸
Women's Health Care at Frost Street, San Diego, California, United States
🇺🇸
Medisphere Medical Research Center, LLC, Evansville, Indiana, United States

and more 9 locations

Patient-initiated Episodic Treatment of Recurrent Genital Herpes in Black Patients

Phase 4

Completed

Conditions: Genital Herpes

Interventions: Drug: Famciclovir
Drug: Placebo

First Posted Date: 2007-05-23

Last Posted Date: 2011-03-28

Lead Sponsor: Novartis

Target Recruit Count: 463

Registration Number: NCT00477334

Locations: 🇺🇸
Perimeter Institute for Clinical Research Inc. ("PICR"), Atlanta, Georgia, United States
🇺🇸
Magee-Womens Hospital of UPMC, Pittsburgh, Pennsylvania, United States
🇺🇸
The Conant Foundation Quest Diagnostics, San Francisco, California, United States

and more 40 locations

Pharmacokinetics, Acceptability and Safety of Famciclovir in Infants (1 Month to Less Than 12 Months) With Herpes Simplex Infection

Phase 2

Completed

Conditions: Herpes Simplex

Interventions: Drug: famciclovir

First Posted Date: 2007-03-16

Last Posted Date: 2011-02-11

Lead Sponsor: Novartis

Target Recruit Count: 18

Registration Number: NCT00448227

Locations: 🇺🇸
Children's Memorial Hospital Chicago, Chicago, Illinois, United States
🇺🇸
Children's Hospital of Michigan, Detroit, Michigan, United States
🇺🇸
Archana Chatterjee, Omaha, Nebraska, United States

and more 3 locations

Drug Development Updates

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