Doxepin
- Generic Name
- Doxepin
- Brand Names
- Prudoxin, Silenor, Sinequan, Zonalon
- Drug Type
- Small Molecule
- Chemical Formula
- C19H21NO
- CAS Number
- 1668-19-5
- Unique Ingredient Identifier
- 5ASJ6HUZ7D
- Background
Doxepin is a psychotropic agent with antidepressant and anxiolytic properties. It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to cidoxepin. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture.
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- Indication
Oral doxepin is approved for the following indications:
Topical doxepin is also approved for short-term (up to 8 days) management of moderate pruritus in adult patients with atopic dermatitis, pruritus or lichen simplex chronicus.
Off-label, doxepin is used topically for the management of neuropathic pain.
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- Associated Conditions
- Anxiety, Bipolar Disorder (BD), Depression, Depression, Involutional, Insomnia, Lichen simplex chronicus, Neuropathic Pain, Neurotic depression, Pruritus, Psychotic depressive disorder
- Associated Therapies
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