Levothyroxine

Generic Name
Levothyroxine
Brand Names
Eltroxin, Ermeza, Euthyrox, Levo-T, Levothroid, Levoxyl, Np Thyroid, Synthroid, Thyquidity, Tirosint, Unithroid
Drug Type
Small Molecule
Chemical Formula
C15H11I4NO4
CAS Number
51-48-9
Unique Ingredient Identifier
Q51BO43MG4
Background

Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T (tetraio...

Indication

Levothyroxine is indicated as replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism. It is also indicated as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.

Associated Conditions
Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism, Localized Adiposity, Myxedema coma, Euthyroid Goitre, Thyrotropin dependent Well-Differentiated Thyroid Cancer
Associated Therapies
-
Clinical Trials
Related News

Thyroxine Replacement Therapy After Lobectomy for Low-risk Papillary Thyroid Carcinoma

Phase 2
Recruiting
Conditions
Thyroid Cancer
Surgery
Recurrence
Interventions
Drug: Thyroxine
First Posted Date
2023-10-17
Last Posted Date
2023-10-17
Lead Sponsor
Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Target Recruit Count
140
Registration Number
NCT06087068
Locations
🇨🇳

Cancer Hospital, Chinese Academy of Medical Science, Beijing, Beijing, China

Dosing of LT4 in Older Individuals

Phase 4
Recruiting
Conditions
Hypothyroidism
Interventions
Drug: Levothyroxine Sodium
First Posted Date
2023-10-10
Last Posted Date
2024-02-23
Lead Sponsor
University of Pennsylvania
Target Recruit Count
228
Registration Number
NCT06073665
Locations
🇺🇸

Penn Medicine, Smilow Translational Research Center, Philadelphia, Pennsylvania, United States

Study of XP-8121 For the Treatment of Adult Subjects With Hypothyroidism

Phase 2
Completed
Conditions
Hypothyroidism
Interventions
Drug: levothyroxine sodium
First Posted Date
2023-04-21
Last Posted Date
2024-07-26
Lead Sponsor
Xeris Pharmaceuticals
Target Recruit Count
46
Registration Number
NCT05823012
Locations
🇺🇸

Panax Clinical Research, LLC, Miami Lakes, Florida, United States

🇺🇸

American Research Corporation, San Antonio, Texas, United States

🇺🇸

Rainier Clinical Research Center, Renton, Washington, United States

and more 3 locations

Effect of Acupuncture and Low Caloric Diet on Primary Hypothyroidism and Irregular Menstruation in Infertile Women

First Posted Date
2023-04-07
Last Posted Date
2023-04-07
Lead Sponsor
Cairo University
Target Recruit Count
60
Registration Number
NCT05804149
Locations
🇪🇬

Eman Sedky, Cairo, Maadi, Egypt

A Study Evaluation the Safety and Efficacy of Hormone Replacement Therapy With North Star Compared to Levothyroxine in Patients With Primary Hypothyroidism

First Posted Date
2023-02-03
Last Posted Date
2023-05-06
Lead Sponsor
Neuvosyn Laboratories, LLC
Target Recruit Count
300
Registration Number
NCT05712421
Locations
🇺🇸

Neuvosyn Investigational Site, Stafford, Texas, United States

Thyroid Hormone for Treatment of Nonalcoholic Steatohepatitis in Veterans

First Posted Date
2022-09-02
Last Posted Date
2024-03-13
Lead Sponsor
VA Office of Research and Development
Target Recruit Count
128
Registration Number
NCT05526144
Locations
🇺🇸

Harry S. Truman Memorial, Columbia, MO, Columbia, Missouri, United States

A Study Evaluating the Safety and Efficacy of Hormone Replacement Therapy With ST-1891 Compared to Levothyroxine in Patients With Primary Hypothyroidism

Phase 2
Completed
Conditions
Hypothyroidism
Interventions
Drug: ST-1891
Drug: Levothyroxine
First Posted Date
2022-06-09
Last Posted Date
2024-08-26
Lead Sponsor
Sention Therapeutics, LLC
Target Recruit Count
490
Registration Number
NCT05412979
Locations
🇺🇸

Sention Investigational Site, Renton, Washington, United States

Fetal and Neonatal Thyroid in Pregnancies With Severe Acute Respiratory Syndrome Coronavirus 2 ( SARS- COV2 ) COVID-19

First Posted Date
2022-05-23
Last Posted Date
2022-05-23
Lead Sponsor
OMER B ABDELBASIT
Target Recruit Count
95
Registration Number
NCT05385029
Locations
🇸🇦

Security Forces Hospital, Riyadh, Central, Saudi Arabia

Influence of Initial Levothyroxine Dose on Neurodevelopmental and Growth Outcomes in Congenital Hypothyroidism

Phase 4
Completed
Conditions
Congenital Hypothyroidism
Interventions
Drug: Levothyroxin
First Posted Date
2022-05-12
Last Posted Date
2022-05-12
Lead Sponsor
Federico II University
Target Recruit Count
72
Registration Number
NCT05371262

TSH Suppression During Radiotherapy on Thyroid Site to Prevent Iatrogenic Hypothyroidism in Pediatric Cancer Patients

Phase 3
Recruiting
Conditions
Hypothyroidism; Irradiation
Interventions
Drug: Levothyroxine
First Posted Date
2022-04-07
Last Posted Date
2023-12-06
Lead Sponsor
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Target Recruit Count
68
Registration Number
NCT05316922
Locations
🇮🇹

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy

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