Levothyroxine
- Generic Name
- Levothyroxine
- Brand Names
- Eltroxin, Ermeza, Euthyrox, Levo-T, Levothroid, Levoxyl, Np Thyroid, Synthroid, Thyquidity, Tirosint, Unithroid
- Drug Type
- Small Molecule
- Chemical Formula
- C15H11I4NO4
- CAS Number
- 51-48-9
- Unique Ingredient Identifier
- Q51BO43MG4
- Background
Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T (tetraio...
- Indication
Levothyroxine is indicated as replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism. It is also indicated as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.
- Associated Conditions
- Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism, Localized Adiposity, Myxedema coma, Euthyroid Goitre, Thyrotropin dependent Well-Differentiated Thyroid Cancer
- Associated Therapies
- -
Recovery Rate in Secondary Hypothyroidism
- Conditions
- First Posted Date
- 2022-03-11
- Last Posted Date
- 2024-08-21
- Lead Sponsor
- Nova Scotia Health Authority
- Target Recruit Count
- 90
- Registration Number
- NCT05276856
- Locations
- 🇨🇦
Nova Scotia Health, Halifax, Canada
Type 2 Deiodinase Gene Polymorphism and the Treatment of Hypothyroidism Caused by Thyroidectomy in Thyroid Cancer Patients.
- Conditions
- Interventions
- First Posted Date
- 2022-02-18
- Last Posted Date
- 2022-02-18
- Lead Sponsor
- Zhongshan Hospital Xiamen University
- Target Recruit Count
- 50
- Registration Number
- NCT05247476
- Locations
- 🇨🇳
Yan Ling, Xiamen, Fujian, China
Use of Tirosint®-SOL or Tablet Formulations of Levothyroxine in Pediatric Patients With Congenital Hypothyroidism (CH)
- Conditions
- Interventions
- First Posted Date
- 2022-02-08
- Last Posted Date
- 2024-04-15
- Lead Sponsor
- IBSA Institut Biochimique SA
- Target Recruit Count
- 126
- Registration Number
- NCT05228184
- Locations
- 🇺🇸
CHOC Children's Hospital, Orange, California, United States
🇺🇸Children's Hospital of Los Angeles, Los Angeles, California, United States
🇺🇸Children's Hospital of Atlanta, Atlanta, Georgia, United States
The Effect of Thyroid Antibodies on Female Reproductive Function and Pregnancy Outcomes
- Conditions
- Interventions
- First Posted Date
- 2021-07-07
- Last Posted Date
- 2021-07-07
- Target Recruit Count
- 4000
- Registration Number
- NCT04952012
- Locations
- 🇨🇳
Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China
The Prevalence and Risk Factors for Thyroid Dysfunction in Pregnant Women in Taiwan
- Conditions
- Interventions
- First Posted Date
- 2021-06-23
- Last Posted Date
- 2021-08-16
- Lead Sponsor
- Chang Gung Memorial Hospital
- Target Recruit Count
- 2000
- Registration Number
- NCT04936698
- Locations
- 🇨🇳
Chang Gung Memorial hospital, Taipei City, Taiwan
Comparison of Levothyroxine Formulation in Hypothyroid Patients With Enteral Feeding
- Conditions
- Interventions
- First Posted Date
- 2021-05-07
- Last Posted Date
- 2023-04-10
- Lead Sponsor
- University of California, Los Angeles
- Target Recruit Count
- 3
- Registration Number
- NCT04878614
- Locations
- 🇺🇸
UCLA Center for Human Nutrition, Los Angeles, California, United States
Study of Resistance to Thyroid Hormone After Long-term Exposure in People With Thyroid Cancer
- Conditions
- Interventions
- First Posted Date
- 2021-04-30
- Last Posted Date
- 2023-02-21
- Lead Sponsor
- Memorial Sloan Kettering Cancer Center
- Registration Number
- NCT04868045
Energy Metabolism in Thyroidectomized Patients
- Conditions
- Interventions
- First Posted Date
- 2021-03-04
- Last Posted Date
- 2024-06-14
- Lead Sponsor
- Virginia Commonwealth University
- Target Recruit Count
- 13
- Registration Number
- NCT04782856
- Locations
- 🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States
Final Height in Patients With CH Diagnosed by the Screening
- Conditions
- First Posted Date
- 2021-02-02
- Last Posted Date
- 2021-10-05
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 60
- Registration Number
- NCT04734457
- Locations
- 🇪🇬
Ain Shams University, Cairo, Abbasiya, Egypt
Thyroid and Adrenocortical Hormone Replacement in Organ Donors
- Conditions
- Interventions
- First Posted Date
- 2020-08-27
- Last Posted Date
- 2020-08-27
- Lead Sponsor
- Medical University of South Carolina
- Target Recruit Count
- 199
- Registration Number
- NCT04528797
Drug Development Updates
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