Levothyroxine
- Generic Name
- Levothyroxine
- Brand Names
- Eltroxin, Ermeza, Euthyrox, Levo-T, Levothroid, Levoxyl, Np Thyroid, Synthroid, Thyquidity, Tirosint, Unithroid
- Drug Type
- Small Molecule
- Chemical Formula
- C15H11I4NO4
- CAS Number
- 51-48-9
- Unique Ingredient Identifier
- Q51BO43MG4
- Background
Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T (tetraio...
- Indication
Levothyroxine is indicated as replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism. It is also indicated as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.
- Associated Conditions
- Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism, Localized Adiposity, Myxedema coma, Euthyroid Goitre, Thyrotropin dependent Well-Differentiated Thyroid Cancer
- Associated Therapies
- -
Recurrent Pregnancy Loss and Thyroid Disease
- First Posted Date
- 2017-04-11
- Last Posted Date
- 2017-04-12
- Lead Sponsor
- Second Affiliated Hospital of Soochow University
- Target Recruit Count
- 300
- Registration Number
- NCT03106935
- Locations
- 🇨🇳
Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China
Effects of Liothyronine on Energy Expenditure and Cardiovascular Function
- First Posted Date
- 2017-03-31
- Last Posted Date
- 2021-03-26
- Lead Sponsor
- Virginia Commonwealth University
- Target Recruit Count
- 22
- Registration Number
- NCT03098433
- Locations
- 🇺🇸
Virginia Commonwealth University, Richmond, Virginia, United States
Interaction Between Levothyroxine and Probiotics in Hypothyroid Patients
- Conditions
- Interventions
- First Posted Date
- 2017-03-30
- Last Posted Date
- 2017-03-30
- Lead Sponsor
- Azienda USL Modena
- Target Recruit Count
- 80
- Registration Number
- NCT03095963
Thyroid Hormone Replacement for Subclinical Hypothyroidism and Chronic Heart Failure (ThyroHeart-CHF)
- First Posted Date
- 2017-03-30
- Last Posted Date
- 2018-03-29
- Target Recruit Count
- 124
- Registration Number
- NCT03096613
- Locations
- 🇨🇳
Chinese Academy of Medical Sciences, Fuwai Hospital, Beijing, Beijing, China
Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectomized Patients
- Conditions
- Interventions
- First Posted Date
- 2017-02-14
- Last Posted Date
- 2023-04-21
- Lead Sponsor
- Azienda USL Modena
- Target Recruit Count
- 160
- Registration Number
- NCT03053115
- Locations
- 🇮🇹
AziendaUSLModena, Modena, Italy
The Effects of T4 Versus T4/T3 on Psychological Distress After Total Thyroidectomy in Thyroid Cancer Patients
- Conditions
- Interventions
- First Posted Date
- 2017-01-18
- Last Posted Date
- 2019-02-22
- Lead Sponsor
- Inje University
- Target Recruit Count
- 150
- Registration Number
- NCT03024151
- Locations
- 🇰🇷
Dongsik Bae, Busan, Korea, Republic of
🇰🇷Dong sik Bae, Busan, Korea, Republic of
Hypothyroidism, Metabolism and Food Intake
- First Posted Date
- 2016-12-15
- Last Posted Date
- 2018-11-06
- Lead Sponsor
- Herlev Hospital
- Target Recruit Count
- 18
- Registration Number
- NCT02993562
- Locations
- 🇩🇰
Center for Diabetes Research, Herlev and Gentofte Hospitals, Copenhagen, Region Hovedstaden, Denmark
Levothyroxine Replacement With Liquid Gel Capsules vs Tablets Post-thyroidectomy
- Conditions
- Interventions
- First Posted Date
- 2016-10-27
- Last Posted Date
- 2020-12-01
- Lead Sponsor
- University of Texas Southwestern Medical Center
- Target Recruit Count
- 14
- Registration Number
- NCT02946918
- Locations
- 🇺🇸
University of Texas Southwestern Medical Center, Dallas, Texas, United States
A Trial Investigating the Influence of Oral Semaglutide on the Pharmacokinetics of Levothyroxine and the Influence of Co-administered Tablets on the Pharmacokinetics of Semaglutide Administered Orally in Healthy Subjects.
- Conditions
- Interventions
- First Posted Date
- 2016-09-30
- Last Posted Date
- 2017-12-14
- Lead Sponsor
- Novo Nordisk A/S
- Target Recruit Count
- 45
- Registration Number
- NCT02920385
- Locations
- 🇩🇪
Novo Nordisk Investigational Site, Berlin, Germany
The TRUST Study - CardioVascular Imaging IMT
- Conditions
- Interventions
- First Posted Date
- 2016-07-14
- Last Posted Date
- 2017-02-28
- Lead Sponsor
- Insel Gruppe AG, University Hospital Bern
- Target Recruit Count
- 184
- Registration Number
- NCT02832934
- Locations
- 🇨🇭
Department of General Internal Medicine, Lausanne, Vaud, Switzerland
🇨🇭Clinic for General Internal Medicine, Bern University Hospital Bern, Bern, Switzerland
🇨🇭Cardiology Division, Geneva University Hospitals, Geneva, Switzerland
Drug Development Updates
Stay informed with timely notifications on clinical trials, regulatory changes, and research advancements related to this medication.