Levothyroxine
- Generic Name
- Levothyroxine
- Brand Names
- Eltroxin, Ermeza, Euthyrox, Levo-T, Levothroid, Levoxyl, Np Thyroid, Synthroid, Thyquidity, Tirosint, Unithroid
- Drug Type
- Small Molecule
- Chemical Formula
- C15H11I4NO4
- CAS Number
- 51-48-9
- Unique Ingredient Identifier
- Q51BO43MG4
- Background
Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T (tetraio...
- Indication
Levothyroxine is indicated as replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism. It is also indicated as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.
- Associated Conditions
- Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism, Localized Adiposity, Myxedema coma, Euthyroid Goitre, Thyrotropin dependent Well-Differentiated Thyroid Cancer
- Associated Therapies
- -
Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypothyroidism
- Conditions
- Interventions
- First Posted Date
- 2013-04-15
- Last Posted Date
- 2018-09-12
- Lead Sponsor
- Shandong Provincial Hospital
- Target Recruit Count
- 400
- Registration Number
- NCT01831869
- Locations
- 🇨🇳
Shandong Provincial Hospital, Jinan, Shandong, China
Desiccated Thyroid Extract and Levothyroxine for Hypothyroidism Treatment
- Conditions
- Interventions
- First Posted Date
- 2012-12-04
- Last Posted Date
- 2012-12-04
- Lead Sponsor
- Walter Reed National Military Medical Center
- Target Recruit Count
- 180
- Registration Number
- NCT01739972
- Locations
- 🇺🇸
Walter Reed National Military Medical Center, Endocrinology, Bethesda, Maryland, United States
🇺🇸Walter Reed National Military Medical Center, Bethesda, Maryland, United States
Thyroid Hormone Replacement for Subclinical Hypothyroidism
- First Posted Date
- 2012-08-08
- Last Posted Date
- 2017-03-13
- Lead Sponsor
- NHS Greater Glasgow and Clyde
- Target Recruit Count
- 737
- Registration Number
- NCT01660126
- Locations
- 🇬🇧
Glasgow Royal Infirmary, NHS Greater Glasgow and Clyde, Glasgow, United Kingdom
Study of Optimal Replacement of Thyroxine in the Elderly
- First Posted Date
- 2012-07-24
- Last Posted Date
- 2015-10-12
- Lead Sponsor
- Newcastle-upon-Tyne Hospitals NHS Trust
- Target Recruit Count
- 48
- Registration Number
- NCT01647750
- Locations
- 🇬🇧
Clinical Research Facility, Newcastle upon Tyne, Tyne and Wear, United Kingdom
🇬🇧Bensham Hospital, Gateshead, Tyne and Wear, United Kingdom
Levothyroxine for Children With Euthyroid Sick Syndrome
- Conditions
- Interventions
- First Posted Date
- 2012-06-29
- Last Posted Date
- 2014-03-05
- Lead Sponsor
- Sinaloa Pediatric Hospital
- Target Recruit Count
- 80
- Registration Number
- NCT01631305
- Locations
- 🇲🇽
Sinaloa Pediatric Hospital, Culiacan, Sinaloa, Mexico
Bioequivalence of Two Levothyroxine Tablet Formulations in Healthy Indian Volunteers
- First Posted Date
- 2012-02-22
- Last Posted Date
- 2013-02-11
- Lead Sponsor
- GlaxoSmithKline
- Target Recruit Count
- 26
- Registration Number
- NCT01536678
- Locations
- 🇮🇳
GSK Investigational Site, Hyderabad, India
Supraphysiological Doses of Levothyroxine as Adjunctive Therapy in Bipolar Depression
- First Posted Date
- 2012-02-08
- Last Posted Date
- 2012-02-08
- Lead Sponsor
- Charite University, Berlin, Germany
- Target Recruit Count
- 74
- Registration Number
- NCT01528839
- Locations
- 🇩🇪
Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany, Dresden, Germany
🇺🇸University of California in Los Angeles, Los Angeles, California, United States
🇩🇪Department of Psychiatry, LWL University Hospital, Ruhr University Bochum, Bochum, Germany, Bochum, Germany
Thyroxin Treatment in Sub Clinical Hypothyroidism, on the Apnea Hypopnea Index Score, Lipids and Highly Sensitive CRP
- First Posted Date
- 2011-12-06
- Last Posted Date
- 2011-12-08
- Lead Sponsor
- King Saud University
- Target Recruit Count
- 200
- Registration Number
- NCT01486667
- Locations
- 🇸🇦
University Sleep Disorders Center, Riyadh, Saudi Arabia
Bioavailability Investigations of Thyronajod Mite Tablets of Dosage Strengths 50 μg Levothyrox-ine/75 μg Iodine, and 100 μg Levothyroxine/75 μg Iodine vs. a Levothyroxine Drinking-Solution: A Randomised Cross Over Study in Healthy Male Individuals. Currently: 100 μg/ 75 μg Tablets
- First Posted Date
- 2011-11-06
- Last Posted Date
- 2011-11-06
- Lead Sponsor
- Heidelberg University
- Target Recruit Count
- 24
- Registration Number
- NCT01465646
- Locations
- 🇩🇪
Clinical Research Unit, University of Heidelberg, Heidelberg, Germany
Bioavailability Investigations of Thyronajod Mite Tablets of Dosage Strengths 50 μg Levothyrox-ine/75 μg Iodine, and 100 μg Levothyroxine/75 μg Iodine vs. a Levothyroxine Drinking-Solution: A Randomised Cross Over Study in Healthy Male Individuals. Currently: 50 μg/ 75 μg Tablets
- First Posted Date
- 2011-11-06
- Last Posted Date
- 2011-11-06
- Lead Sponsor
- Heidelberg University
- Target Recruit Count
- 24
- Registration Number
- NCT01465633
- Locations
- 🇩🇪
Clinical Research Unit, University of Heidelberg, Heidelberg, Germany
Drug Development Updates
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